00:00Please welcome Jeremy Berkhoff and Ilona Cazzo from Sonomide.
00:09Give me more energy, this is the last one, so help me to provide love with Jona and Jeremy.
00:20What do you feel like?
00:28Good afternoon everybody, this is Thomas, everybody see Thomas.
00:37Thomas is not doing well, right Dr. Cazzo?
00:41No he's not, Thomas is really sad, Thomas doesn't eat, doesn't talk to his relatives and he's slowly isolating.
00:50He takes medications for that, it's been years and many of them, but nothing seems to work.
00:58According to you guys, what is Thomas suffering from?
01:03So now you take your phones, you scan your, the QR code and you try to vote.
01:13We're waiting for the participants to increment, I want at least 20 participants.
01:21Yeah, great, there we go, we have it.
01:24Great, great, come on.
01:31Okay, one more second, oh 33.
01:37So, let's go.
01:42Well, are there results coming up?
01:44Yeah, you're 100% right.
01:46Thomas is suffering from treatment resistant depression.
01:53Yes, the figures are coming up again, so treatment resistant depression.
01:57I think we can go to the next slide for that.
02:01Okay, you're right.
02:08Today, people suffering from treatment resistant depression or TRD are more than 100 million people in the world.
02:20This represents around $1,000 billion spent in treatments worldwide in 2020.
02:30Today, people like Thomas, and they represent 30% of these patients, they have only two options.
02:39They are pretty invasive and sometimes they're painful.
02:43It can be electroshock or it can be RTMS or DBS, which is highly invasive, and surgical solutions.
02:53So, you understood it's for this more than 1 million Thomas that Sonomind exists.
03:00So, Sonomind is a medical device that uses ultrasound to treat depression.
03:07The same ultrasound that are used to image a baby before it's born, we use it to heal the brain.
03:14We send the ultrasound deep inside the brain at the location that are affected by the diseases.
03:22It's non-invasive, it's painless, and it's extremely precise.
03:30How do we do that?
03:32So, we build for Thomas a custom lens and a custom mask that is deduced from the MRI of Thomas'
03:42head.
03:43We printed in 3D the two elements.
03:48This lens that Dr. Cazzo is showing you is the result of 25 years of research at Institute of Physics
03:56for Medicine in Paris.
03:57It will guide the ultrasound waves from the system to inside Thomas' brain by guiding the waves through the bones
04:08of Thomas
04:09and localizing them, as you can see, exactly at the location where Thomas needs it.
04:16So, it's a millimeter precision.
04:20And so, according to you, what is the mechanism of ultrasound that are involved in this treatment?
04:41Second question.
04:43Scan again.
04:44You're on?
04:45You're on.
04:46Let's go.
04:49Is it an electric shock inside the brain?
04:53Is it a neuronal massage?
04:57Is it a thermal effect?
05:00Or is it what we call cavitation?
05:02So, it's a bubble that we create remotely to shake the tissues.
05:11Okay, this one is more difficult.
05:25You're good.
05:26It's a neuronal massage.
05:28So, ultrasound, we do a massage of the neurons at the location that we focus.
05:33And neurons that have a massage, like humans, they communicate better between them.
05:39And when the neurons communicate better between them, Thomas feels better.
05:48So, I'm switching back.
06:02So, the first results of our first case study that happened in Paris at St. Anne Hospital has shown spectacular
06:12results.
06:12In only five-day treatments from patients who were suffering from treatment-resistant depression for years.
06:20They have shown results in only five days.
06:23And the only second effect that we could measure was a bit of tiredness.
06:28So, no serious second effects that was observed on the patients.
06:32So, five days of treatment, one hour of ultrasound per day, five days of treatment.
06:37And we proved that we can heal depression.
06:41This is only 15 patients.
06:4315 patients is a promise, it's not a result.
06:45So, we just raised 20 million euros this month to run international clinical trials, double-blinded against placebo, to demonstrate
06:57our efficacy.
06:57And we hope to be in the market by 2029.
07:02And we will not stop with depression.
07:04We can change the location where we send ultrasound and we can heal other diseases.
07:11So, depending on the area, we can treat obsessive constipative disorder.
07:21We can treat addictions.
07:24We can treat anxiety.
07:25We can treat chronic pain.
07:28We can treat Parkinson's.
07:31So, the possibilities are huge.
07:34We didn't build a treatment for depression.
07:37We built a platform to heal the brain.
07:41We know that one day, Thomas in here will feel better.
07:46And tomorrow, all the Thomases in the world.
07:51And that's exactly what our mission at Sonoma.
07:54So, we wait for you in 2029 for our system to be on the market.
08:03Thank you very much.
08:14Questions?
08:15Ladies and gentlemen?
08:20No.
08:21I saw a cell phone like this.
08:23I thought it was a question, but no question.
08:26Okay.
08:27It's just a picture.
08:28It's not a question.
08:28Okay.
08:29There's a difference.
08:31No questions.
08:32Quite clear.
08:34Thank you so, so much.
08:36Ilona.
08:37And Jeremy.
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