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00:0013 Medications and Supplements That May Help Slow Brain Aging
00:03A study identifies 7 genes and 13 drugs targeting brain aging,
00:09offering strategies against neurodegenerative diseases and cognitive decline,
00:14potentially saving $7.1 trillion with a 2% aging delay.
00:22The study analyzed MRI data from 39,000 UK biobank participants
00:27to estimate biological brain age, identifying 7 genes like MAPTEN-TNF-SF12 linked to Alzheimer's
00:34and neuroinflammation processes.
00:39The 3DVIT model accurately predicts brain age via MRI scans,
00:45off by 2.64 years, highlights key brain regions as biomarkers.
00:50The study identifies 13 drugs targeting 7 genes to mitigate brain aging.
00:59Notable drugs include metformin, hydrocortisone, testosterone, diclofenac,
01:05dacetinib, docnexant, colocalciferol, estradiol, mechamylamine, nicotine,
01:12prasterone, quercetin, resveratrol, and sirolimus.
01:16Researchers urge caution, highlighting potential risks.
01:21Repurposing these drugs offers a cost-effective strategy,
01:25as Dr. Yi Cheng-Ju notes, translating genetic insights into practical therapies.
01:33Targeting BAG-related genes may reduce neurodegenerative risks and enhance cognition.
01:39Broader studies beyond UK Biobank are needed to ensure global relevance.
01:43Brain aging's genetic basis involves gene, lifestyle, and environment interactions.
01:52Future work should integrate genomic and machine learning for therapeutic targets.
01:56Başkapecimusaka البacиеa
01:57Wim economic and machine learning for therapeutic methods.
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