Researchers Identify New Subtypes of Common Brain Disorder

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00:00Researchers identify new subtypes of common brain disorder.

00:05Despite decades of study, key-ary type 1 malformation remains elusive, with unknown causes and limited

00:12treatment options, mainly surgery.

00:15Affecting up to 4% of the population, it involves the brain protruding over 5 mm into the spinal

00:22cord gap.

00:23Key-ary type 1 malformation's symptoms vary, causing treatment challenges.

00:29Some remain symptom-free and others face severe issues, complicating consistent treatment

00:35development due to unpredictability.

00:38Researchers at Washington University identified three subtypes of key-ary type 1 malformation,

00:45enabling customized treatments by recognizing distinct characteristics, potentially reducing

00:51brain pressure and alleviating symptoms through surgical intervention.

00:55Key-ary malformation ranks high in surgical causes, yet not everyone benefits from surgery.

01:02It's crucial for headaches and syringomyelia, though symptoms can persist post-surgery.

01:08Dr. Sean Gupta highlights that 4% of people have key-ary malformations, mostly symptomless.

01:16Treatment is uncertain due to many variables.

01:19AI tools now help analyze extensive data, potentially improving understanding and treatment of key-ary

01:25malformations.

01:26Ziki Xu, a study co-lead, developed an AI algorithm analyzing over 500 variables, revealing three

01:34key-ary disorder subsets.

01:37The first subset mainly includes females diagnosed later with severe headaches.

01:43The second subset is younger patients with fewer headaches, but more motor issues.

01:49And the third subset has spinal abnormalities, requiring frequent decompression and spinal surgeries.

01:56Dr. Gupta highlights AI's role in forming guidelines for key-ary treatments by providing deeper insights,

02:04promising evidence-based consensus, and improving outcomes through informed decision-making and

02:10extensive data analysis.