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00:00I'm creative.
00:07I don't see creativity being limited to artistic endeavours.
00:13Actually, it's there to be applied to everything.
00:18And applying it to a tricky scientific question is brilliant.
00:26You've got to think big.
00:30You've got to dream the dream.
00:37Cancer is a huge adversary that's trying to hoodwink you.
00:43Well done, Gary. Nice deep breaths for us.
00:46One, two, three.
00:49But now we're at the dawn of a new series of cancer treatments.
00:54We have the opportunity to change medicine forever.
00:58For generations, a cancer diagnosis left almost no hope.
01:04It's a terrifying disease that has stalked us for millennia.
01:10I didn't expect I had cancer because all the tests were coming back negative.
01:13I don't think my body can take any more.
01:16Science has fought hard against it.
01:19And now the tide is finally turning.
01:21One of our key goals is to transform this idea of cancer as a death sentence.
01:26A group of trailblazing scientists are making new breakthroughs.
01:32We now need to take those discoveries and make them work for patients.
01:38This is the world's first lung cancer prevention vaccine.
01:42Discovering cures and finding ways to stop cancer before it even starts.
01:48The tumour seems to be shrinking.
01:50Your scan shows no active disease.
01:53Creating a future...
01:55Where cancer doesn't win.
01:58We're getting very close to defeating cancer once and for all.
02:02What's not curable today could be curable tomorrow.
02:27It's been evolving with us throughout the history of humanity.
02:32It's a notorious killer and very good at growing, but very bad at dying.
02:46Cell division is vital to life.
02:50Most of your cells in your body will divide at some point.
02:53A mutation is an error in the code that every cell has within its nucleus, its DNA.
03:03Mutations are happening in your body right now, but your immune system is very good at removing them.
03:09Your body has lots of mechanisms to deal with interlopers and problem cells.
03:15What cancer is very good at is evading those natural mechanisms.
03:21Mutations cause cells to grow when they should have stopped.
03:27And that can cause major problems for your body.
03:31And that can cause major problems for your body.
03:37Try not to move your head, Gary.
03:39In the battle against cancer, neurosurgeon and scientist Richard Mayer specialises in fighting one of the disease's deadliest forms.
03:49Glioblastoma, a type of brain cancer.
03:54While there have been advances in treating many cancers, no one has made real progress against brain cancer for decades.
04:00Richard is determined to change that.
04:03I think there is something brilliant about everyone saying you can't do it and saying, well, sod you, I can.
04:15So there's a little bit of the defiant spirit.
04:18You have to think outside the box.
04:21Making good progress.
04:23Brain cancer is a very difficult disease to treat.
04:28The treatment at the moment revolves around three distinct steps.
04:32First is surgery.
04:35Second is radiotherapy.
04:38And then chemotherapy.
04:40Which works reasonably well in about a third of patients and in two thirds of patients less well.
04:47And that's been the standard of care now for 30 years and we haven't seen any changes in standard of care over that time.
04:56And so from our perspective, that seems like a long time, especially when average survival is a little over a year.
05:04You've done really well.
05:07Richard plans to revolutionise brain cancer treatment, but he's up against a formidable enemy.
05:15Brain cancer is often fast growing and symptoms can appear out of the blue.
05:25What did you have for lunch?
05:26I had a jacket at the same time.
05:28Oh, they've got the good cheese again.
05:29Yeah.
05:34Come on then. Give us a hug.
05:37Yeah.
05:39My name's David.
05:41Go sit down, have your drink.
05:43Take him in.
05:44I live with my wife, Laura.
05:49And my daughter, Lucy.
05:55We were on a walk and I suddenly had a dizzy spell.
06:00Followed by, at that stage, it was just like a phantom smell.
06:05And I continued to have them sporadically.
06:07So I started pursuing the doctors and I got diagnosed with everything from inner ear infections, upper respiratory infection.
06:18And then they settled on sinusitis and I had all sorts of medications.
06:23And then a month ago, I had a seizure where I actually passed out and collapsed.
06:29But at first I thought maybe he was having a stroke or a heart attack, he clutched his chest, his face dropped, but then his whole body, you know, he just collapsed, he was shaking all over, struggling for breath.
06:41And, you know, everything was clenched up and then I realised it was a full seizure.
06:46David underwent a scan.
06:48It showed a large tumour on his brain.
06:52Within a week, he's sent to Richard at Attenbrookes Hospital in Cambridge.
07:04So David, not uncommonly for one of my patients, has had a seizure, which means he's had a fit, and that's likely related to this tumour that we found.
07:15So obviously that can generate a lot of anxiety and we need to treat those seizures that he's got, but obviously we also need to treat the underlying tumour, and that's what we're going to talk about today.
07:25Come through. Nice to meet you.
07:31Come through. Nice to meet you.
07:34Nice to meet you.
07:35I'm Richard. Come through.
07:41My name's Richard Mare, one of the Consultant Neurosurgeons.
07:44So, what we can quite clearly see is asymmetry with an area of abnormality here, OK?
07:53My concern is that this represents some form of tumour, OK?
07:57And that may be a malignant form of tumour, so a type of cancer.
08:01So there are three options in neurosurgery.
08:03One, we do nothing.
08:04We watch it.
08:05But I think if we were to do that with serial MRI scans, say every couple of months, my worry would be that this would increase in size quite quickly.
08:15Second option would be to do a biopsy, which would tell us what this is, but it wouldn't remove any of it.
08:22The third option would be to try and do what's called a debulking operation.
08:27We take out as much of the bulk of the tumour as we can, and we send some of that off for analysis.
08:32So we make a diagnosis, but we also try and remove as much as we can safely.
08:38All right.
08:39So I think of those three options you discussed with my colleague, the plan was for debulking.
08:44Yes.
08:44Is that right?
08:45Yes.
08:45OK.
08:46Any questions about that at all?
08:48We're happy to follow your recommendations.
08:52All right.
08:53Fair enough.
08:54Even though there seems to be a sort of well-demarcated region on the brain, on the scan, for where this tumour exists, we will not be able to get out absolutely everything, and it is just debulking.
09:06It's taking out the bulk of it.
09:08OK.
09:09So the results are normally a week, and then after that we can make plans for anything we need to do subsequently.
09:14OK.
09:15Good.
09:16All right.
09:17Nice to meet you both.
09:18Thank you.
09:19Yeah.
09:20And I'll see you tomorrow.
09:21Yes, thank you.
09:22Take care.
09:23See you soon.
09:24Bye now.
09:25My concern is that this is some form of malignant brain tumour, most common being a glioblastoma,
09:29but until we've actually done the operation and got the results back, we try not to predict too much.
09:38Glialblastoma is Richard's greatest nemesis, as it's almost always fatal.
09:45When you see these patients week in, week out, telling them, I'm very sorry, but there's nothing we can do.
09:53Right?
09:54Absolutely nothing.
09:55I think if that doesn't motivate you to try and turn the train around, then I don't know what will.
10:02Richard's frustration has inspired him and a colleague to pioneer a revolutionary new approach to treating brain cancer.
10:11A clinical trial using personalised treatment.
10:17I think this could absolutely change medicine for good, because what we're trying to do is understand really the molecular level of what's going on in these tumours.
10:26Richard's plan is to pinpoint the specific genetic mutation causing each patient's cancer from hundreds of possibilities.
10:35Then, as quickly as possible, to match the patient with a drug thought to work against that precise mutation.
10:46The whole process used to take months, months that patients didn't have.
10:50Richard found a way to do it in weeks.
10:54So this is a world first because we're putting together precision therapies and targets that we've identified in real time using whole genome sequencing.
11:05And we think by bringing all of that together, it gives us a much better chance of finding a genuine treatment that's going to work for these patients.
11:13Just a day after his appointment, David is going under the knife.
11:19Obviously, it's very, very real now.
11:24But basically, I just want to get it over and done with.
11:27Just get this part out of the way.
11:29Get the first step out of the way.
11:32Just wake up, basically.
11:37Then go from there.
11:39Good morning, David.
11:40Hiya.
11:41How are you getting on?
11:42Yeah, all right.
11:43Did you get any sleep?
11:45On and off.
11:46On and off.
11:47Hmm.
11:48Okay.
11:49Someone will come and collect you, take you upstairs, and then we'll get on with it.
11:52Yep.
11:53All right.
11:54Keen to get it out of the way.
11:55Yeah, indeed.
11:56Absolutely.
11:57All right.
11:58Well, I'll see you upstairs.
11:59Yes.
12:00Okay.
12:01Thank you.
12:08What's your favourite place in the world?
12:11With my family.
12:13With your family, yeah?
12:14Yeah.
12:15Sorry.
12:16For David, family life came late.
12:23Wait for us.
12:24Playtime.
12:27I was very nervous about becoming a father at 50.
12:30But I was there at the birth.
12:31And when she came out, that's when it changed.
12:40You know, there was instant love there.
12:43And it's just been an enjoyable experience from then to now.
12:53She's always coming up with something new.
12:56And yeah, it's just a pleasure to be around.
13:00He makes her laugh all the time and they're little jokes.
13:03I'm doing this for GCSE.
13:05I did an engineering.
13:09He's a big softie.
13:10Let's her get away with a lot.
13:12Three.
13:13When you get ill.
13:14Well, it makes life more precious.
13:18But not just your own.
13:22You start thinking about others, especially the ones close to you.
13:25You know, if the worst happens, I want them secure.
13:35I want to know they're not going to struggle.
13:40I don't know what I'd do without it.
13:42Sorry.
13:43This is just some oxygen, nothing else, all right?
14:06Nice big breaths, David.
14:08All right.
14:10That's it.
14:11Yeah, of course.
14:13Oh, lovely.
14:15The sun's shining.
14:17Having the best round.
14:26In my childhood, my parents had a really big bookshelf
14:30that was full of loads of books that were off limits.
14:34And there was a book that looked like it had been well thumbed through.
14:41And it was called Grey's Anatomy, an anatomical textbook.
14:47The book showed that there were other worlds that could be explored that might be interesting.
14:53Probably that's what does drive me, is that there's something under the hood I don't understand.
14:57And can we get down to the bare bones of what's going on?
15:05Okay, it's a pin.
15:10Right, roll on three.
15:11One, two, three.
15:13And back.
15:14With David anaesthetised, the operation to remove his tumour can start.
15:20If the tumour does turn out to be glioblastoma, David's best hope would be if Richard could match him to a drug on the pioneering trial.
15:28Well, good. Okay. Can we make sure he has a strap, please?
15:34Yeah.
15:36It's very privileged, you know, to be able to look at someone's brain without wanting to sound strange is a great privilege.
15:42And it's one that no one takes lightly.
15:49Knife back, please.
15:53Brain surgery has the risk of a terrible, disastrous outcome not that far away.
16:01Daryl, please.
16:02You can inadvertently damage something that leads to the patient's death or significant disability relatively easily.
16:18And so you have to be concentrating throughout the operation to a very high level.
16:28Bone flat.
16:30Right, scope in then, please.
16:36Now, that's tumour, isn't it, there?
16:40Yeah, that's obviously tumour.
16:42A lot of cancers, when you come to operate on them, they look like well-demarcated lumps.
16:50And you can be relatively confident that you've got all the tumour out.
16:55With a primary brain cancer, that's not the case.
16:59Glioblastomas are a group of tumours that are related to certain genetic mutations.
17:06What this leads to is an uncontrolled cell growth, and the way these cells grow and move is like tendrils leaching out from where they've started.
17:18Meaning that there are these long trails that go into the normal brain.
17:23The cells will infiltrate deep into the brain, and you can't cut them out, you can't even see the edges.
17:29Because you have cells that are proliferating, and cells that can migrate and invade into tissues.
17:33And that's why it's called cancer, because it's the claws of the crab.
17:37What that means is it's essentially like trying to unpick two tins of paint that have mixed together.
17:43You just can't do it.
17:45Because we all would love to be able to take every last cell of the tumour.
17:50But we know that's impossible.
17:51So this is definitely tumour.
17:54Thank you.
17:56A bit more tumour coming out.
18:02The hope is, there is a drug on the trial which can treat any tumour left behind.
18:07To pinpoint the right drug, samples of David's tumour are collected for genome sequencing to map its genetic code.
18:21Wonderful, thanks David.
18:22Thanks everyone.
18:24Send to the next.
18:26It's alright.
18:28Dave, we're just taking you around to recovery ward, okay?
18:30Hi there, it's Richard, the surgeon here, calling from Addenbrookes.
18:39Hiya.
18:41Everything went really well.
18:42He's woken up in recovery.
18:44I was very pleased with how the surgery went.
18:47I managed to get out everything that I wanted to.
18:50I can't get out everything, obviously, but I was really pleased with the amount that we managed to remove.
18:55Oh, that's fantastic. Thank you for calling me.
18:57Okay, no problem at all.
18:58That's a really big relief. Thank you very much.
19:00Alright, you take care now.
19:01Okay, thank you.
19:02See ya. Bye.
19:03Bye.
19:09With brain cancer, time is of the essence, so David's tumour is rushed to the lab.
19:15If it is cancer, they then need to find out which specific mutation is the cause, so they can match it with an existing drug.
19:21That's done through genome sequencing, which once took a very long time.
19:29Whole genome sequencing used to be something that was, you know, otherworldly, that was, you know, brand new, took forever, was so expensive you had to batch the samples together, which means you could only run them once every month or two.
19:43And that's not the case anymore. The costs have come down, our pathways have got better. So actually people can be put in for whole genome sequencing as they get on and have their treatment.
19:55So really getting those results back more quickly is much more possible.
20:00This would have been impossible five years ago. Just getting the infrastructure, the sequencing, the analysis, the drugs, this is, you know, on point for something that is, is groundbreaking.
20:17It's been a week since David's operation.
20:23Today is results day for David. So we're going to get him into the clinic and we'll talk him through what his tumour has come back as, what pathological diagnosis this is, and also how much we managed to remove that surgery.
20:38It's a big day for him. Yeah, it's a big day.
20:40One of my first neurosurgical mentors told me that it's important to give people hope. And similarly, it's important to be realistic.
20:56To be realistic. And we used to always skirt around cancer in terms of mentioning the word and talking about prognosis.
21:06So I think it's important to get a balance of both. And that's what I try and do.
21:10David, if you want to sit there. All right. Oh, God.
21:23So you're obviously here for results. So we have been able to make a diagnosis and it has come back as some form of tumour.
21:32OK. And it's a malignant type of tumour. So a type of cancer. And it's called glioblastoma.
21:39It's a cancer that's treatable, but it's not curable. OK. Any questions about that diagnosis at all?
21:48No, I think we were pretty much expecting that. Yeah.
21:51Because we've always trusted your confidence and your ability. We have read up on these sort of things.
22:02What's not clear is just what happens next, really.
22:06OK. Well, let's start with the scan. So this is the post-operative scan on the left. This is pre-operative on the right.
22:12And so what we can see is there's a good amount of the lump that's been removed. But as I mentioned prior to surgery, not all the cancer will have gone.
22:22Because unfortunately, we can never remove all of the cancer. So given that there will still be cancer cells there, the next stage of your treatment is to go for radio and chemotherapy.
22:34Yeah. All right. We also sent your tumour off for DNA sequencing, as we mentioned. The results from that may or may not direct what we do next.
22:44How long will chemo and radiotherapy keep this at bay?
22:48OK. So you're talking about prognosis. Is that something you want to talk about today?
22:53Yeah, we have discussed this.
22:55Yeah. So prognosis is an average. So it's not a specific figure for you personally. But on average, survival is in the region of about 14 and a half months.
23:10So traditionally, students don't like coming to our clinic because it's full of bad news. And it is a very difficult environment to work sometimes.
23:21But I do think if you can do something that's difficult and not very nice in a compassionate and empathetic way, then you can gain some sort of satisfaction from that. But it is tough. It's horrible. You're telling people the worst news they've ever heard in their whole life.
23:40Just go home.
23:41You know, we've got a young daughter. Sure. We want to spend any, you know, what time is left is precious. Sure. Absolutely. Extremely precious. Absolutely.
23:54And we want to make the most of it. It's all I want now. It's been time with you and Lucy.
23:59Just hoping it would have been a bit longer. OK.
24:02How many people have, like, gone on past the, you know, 12, 14 months?
24:07I mean, we have a kind of 5% to 7% five-year survival. OK? It's an average. OK? So let's hope you're on the other side.
24:15Let's face it, Laura, I've never been average, have I?
24:18Or lucky.
24:20Of course I've been lucky.
24:21You'd better win on that scratch card. Of course I've been lucky.
24:24Don't stop.
24:29You're all right?
24:32OK?
24:34He doesn't know at the end of the day you know you've been loved, you know you will be loved right up to the end.
24:39But they're going to be happy times what they've got on. OK?
24:45Take care.
24:46You too. OK. All right. I'll see you.
24:51What am I going to do without him?
24:53I'm sorry.
24:55Just try and check it out a bit, please, for me.
24:59I don't like seeing the licep, so it's even more.
25:02Oh, no. Just give it up.
25:04It's, erm, it's really tough for them, really tough.
25:06David's got a lot of positives despite this overwhelming negative.
25:12He's had a good operation where we've managed to get a large chunk of this tumour out.
25:16He's well.
25:18And when we get his whole genome data back, we can look and see whether there are mutations or alterations in his DNA and regions that we can target with drugs that we've got on our clinical trial.
25:30What we want to do is transform this idea of cancer as a death sentence into something that can not only be treated, but that can be treated to give people a normal quality of life.
25:47Richard's revolutionary trial aims to rewrite the script.
25:50One of the first patients to join the trial was Amanda, a former finance director.
26:01You put half a pack of butter on this, did you?
26:05Yeah.
26:06Not that I'm complaining.
26:08Almost two years ago, Amanda had surgery and post-operative treatment for a glioblastoma.
26:15You've got a dirty face. You've been digging again.
26:17But a few months ago, Amanda's tumour returned.
26:26Patients with brain cancer will unfortunately recur very quickly.
26:32If it takes months to get the results of the DNA analysis you're going to use to plan their treatment, they may have already died by the time we get those data.
26:44Amanda, pre-cancer, she worked 15 hours a day, 16 hours a day. She was up London looking after the grandchildren. She had come back and hit work.
26:59I've looked at these for years. These wedding photographs.
27:07Long time ago, eh, Amanda?
27:10Yeah.
27:11And it seems like yesterday.
27:14Sit down, baby.
27:16I'm with her 24-7. I love it.
27:19Push.
27:20Push.
27:21Push.
27:22But break your leg.
27:23No, you won't.
27:24Go on.
27:25Push.
27:26Like, I'm going to get her breakfast, I'll get her tablets first thing in the morning, give it to her.
27:31And it's just, because she'll forget and I'll go, you ain't took your tablets. Amanda, just take your tablets.
27:37I look at it, it's me job.
27:40Ready?
27:41Yeah.
27:42Oh.
27:44Thank you.
27:45Come on then.
27:46Come on.
27:47Gary's very, very kind.
27:51He worries about me and he gives me lots of support, especially now.
28:00Brain cancer robs the person of themselves. As it grows, it takes away that individual's personality, their ability to function in this world.
28:11And I really hope that our current approach will get some of that back for the patient to try and enable a normal life.
28:20To improve Amanda's future, Richard sought to get her onto his trial. So, he analysed her tumour's DNA to see if it had a mutation that matched one of the trial drugs.
28:36It's vitally important that we have the results back quickly so that we can plan what treatment and get them in a clinical trial as soon as possible.
28:45And that's in a period of weeks, not months and certainly not longer than that.
28:54When Amanda's cancer DNA was examined, a mutation was found that matched a drug on the clinical trial.
29:02I was really surprised to find out that there was still some hope for me.
29:10And my oncologist informed me that Richard would be phoning me to ask me to see if I was interested in joining this trial.
29:22I was really pleased at that. I was thrilled, actually. We both were.
29:28How much hope do you think we get from it?
29:33That's all you have to do, man. Hope? Hope, yeah.
29:38That's all you've got is hope.
29:42Yeah.
29:44But I want more.
29:47Well, it's going the right way at the moment.
29:49Yeah.
29:52Time is everything.
29:54But a new treatment might just give me a little bit more time.
29:59My cups always are full.
30:02So they always give you hope that they'll do something else.
30:05And it's hope.
30:07And that's all you can ask for is hope.
30:10And therefore, if there's a chance of a hope, I'm with Amanda.
30:13You'll be all right.
30:21What we're doing at the moment is trying to help the patients of today.
30:27But that will also help the patients of tomorrow.
30:43It's in there. Oh, thank goodness.
30:50Amanda's now been on Richard's clinical trial for three months.
30:55I feel so much better than I did when I was on the chemo.
31:00So I'm hoping that these are all good signs.
31:03As part of her routine, Amanda has regular MRIs that take detailed images of her brain.
31:15I have to have them frequently in order to plot any changes to my tumour.
31:24And if there are no changes, yay!
31:28They're not a problem for me at all.
31:30And in fact, it's a reassuring confirmation, clarification of your current situation.
31:39So precision therapies are an interesting way of addressing cancer.
31:45We know that in a majority of patients, they have specific mutations that we can target with drugs.
31:55A precision drug has to have a target.
31:57What we need to work out is which of those targets and which of those drugs work in which patient.
32:10A few weeks later, Amanda is back in Cambridge for an appointment with Richard and to collect the drugs she's taking on his trial.
32:16Thank you.
32:19So we got that door.
32:25So the part of the clinical trial that Amanda is on involves taking drugs that work on the kind of mutations we found in her cancer's DNA.
32:32Once these drugs were absorbed into Amanda's body, they travel to the tumour in her brain and into the cancer cells.
32:45The mutations in the cancer cells DNA are causing too many out of control signals to be produced, telling the cancer cells to keep growing when they shouldn't.
32:59The drugs work by blocking these overactive signals to prevent cancer cells from multiplying and to prevent cancer cells invading Amanda's brain.
33:08In theory, that means the tumour should stop growing or even shrink.
33:14Be brave.
33:15Oh, yeah.
33:16Yeah, yeah.
33:17You're a funny lady.
33:18I know.
33:19Come on, then.
33:20So I'm about to see Amanda.
33:21It's great to, you know, see how she's getting on.
33:23Like most people here, all you do is you just hope that it works.
33:44And that's what you want to do, innit?
33:50Yeah.
33:51We just need to be positive all the time, don't we?
33:54Yeah.
33:55Hi there, come and have a seat.
34:00Thank you.
34:01How are you doing?
34:02Great.
34:03Good to see you both.
34:05So I guess we're here to look at your scan, so we probably should start with that.
34:12This is you at the beginning of February, and this is the scan from June.
34:17And I hope you can sort of appreciate that that sort of distance there is a little bit smaller on that scan.
34:22Oh, definitely.
34:23Yeah?
34:24Yes, I can see that.
34:25Yeah.
34:26I think that's very, very encouraging, really.
34:28Yeah.
34:29There's definitely no increase in size in the lump, which is good, and perhaps it's actually shrunk a little bit.
34:36Which is really, really encouraging, given the fact that you're on this trial, and that's something that we are looking for.
34:43Okay?
34:44Yeah.
34:45We're excited, aren't we?
34:46I'm amazed.
34:47And how are you feeling?
34:48How are things?
34:49I feel absolutely fine.
34:50Yeah.
34:51Okay.
34:52Any symptoms at all?
34:53No.
34:54No.
34:55She's getting stronger.
34:56Okay.
34:57Good.
34:58She's getting more and more back to normal.
35:00Okay.
35:01Although she's got a long way to go, but from where she was, she's doing absolutely fantastic.
35:07Okay.
35:08Well, that's fantastic news.
35:09And as I say, from our perspective, you know, we knew that you had these targets within the tumour, these changes in certain genes.
35:17Yes.
35:18That made this new type of treatment, which sort of specifically targets those changes rather than the generic chemotherapy.
35:25Yes.
35:26Right.
35:27As an appropriate thing for you.
35:28Yeah.
35:29So that's a really, you know, good thing that we were able to find that.
35:33And to match that change to a drug, you know, through the clinical trial, obviously, hopefully, and certainly at the moment, is going to have some sort of benefit.
35:41But it's in herself.
35:42Yeah.
35:43Indeed.
35:44Yeah.
35:45The fact that she's feeling better as well.
35:46Yeah.
35:47Yeah.
35:48Yeah.
35:49He just wants me to start cooking again.
35:52Yeah.
35:54I don't know about that.
35:55Yeah.
35:59My wife is a nurse.
36:11And when we discuss our day at work, it often relates to bad news.
36:19And I think it does give you a frame of reference.
36:24Okay, is dad's home?
36:26Have you had a good day?
36:27Yes.
36:28Yeah.
36:29Yeah.
36:30Most of the patients I see had planned for the future, and boom, it's gone.
36:37And I think the thing I take home from that is make sure you enjoy what you're doing, you live your life to the full, and enjoy it.
36:47Okay, have you been playing on the trampoline?
36:49Yeah.
36:50Oh, well done, mate.
36:52That was excellent.
36:53Family helps people get through difficult times.
37:05I think it's really important.
37:06I think it's really important.
37:07And I can see how families strengthen each other.
37:12Hello.
37:13Did you have a good day at school?
37:14Yeah.
37:15Oh, fish.
37:16It's been two months since my operation, then I had my chemo and radiotherapy.
37:32It's been two months since my operation, then I had my chemo and radiotherapy.
37:45I'm in trouble this year.
37:46You slowly come to terms with it.
37:51I think you have to.
37:53Or else he's just going to eat you up.
37:57So now it's just, I just relish my time with my family, really.
38:03So many people inquire now.
38:05We have to put five rows of benches instead of four.
38:08You're getting too good.
38:09You need to be off key a bit more now and drive people away.
38:14No.
38:15Lucy's the biggest focus.
38:17I spend a lot of time with her.
38:20Try and keep things normal.
38:22Right, another day closer to end of time.
38:25Lucy's coping with it very well.
38:27I mean, she's just, she just keeps reminding me I've got to get better.
38:34At this time, I am waiting to hear from the neuro-oncologist about the trial.
38:43What are you up to, Goose?
38:45What are you playing?
38:47Well, I'm hopeful for myself and hopeful for my long-term prognosis, you know,
38:54that I will get onto a clinical trial.
38:58Yeah, where you got to on your hospital game?
39:01You've got a radiotherapy department on your hospital.
39:05That's where daddy goes a lot.
39:07I really hope it works.
39:09And I hope it works for other people as well.
39:12You know, it's not just about me.
39:16My hopes for David are that we have a target.
39:20And that with that target, we can put him on a trial.
39:23And that he has a good outcome from that trial.
39:26You know, every patient I see now, in the back of my mind, I'm thinking, do they have a mutation?
39:33Can we put them on the trial?
39:35And will we see improvement?
39:37Which I think is amazing.
39:39And that's something that I've never experienced before.
39:42All right, you comfortable?
39:47I am.
39:48Are you all right?
39:49Very comfy.
39:51Five months into the trial, and Amanda is still responding well to treatment.
39:58Ta-da!
40:01Look at Gaz's face.
40:03Look at this beautiful evening.
40:10Yeah, we're lucky.
40:12Now we can plan for our future.
40:14It's lovely to look forward to something like that.
40:17Booking holidays and picking places to go to.
40:22How much do I love you? Answer that.
40:25Do you love me enough to buy me a boat?
40:27I don't know about that.
40:29I think if it weren't for the clinical trial, Amanda may well have progressed.
40:37And her quality of life would have been impaired.
40:40Obviously with the trial drug, it's gone the other way.
40:44It's actually shrunk.
40:45And obviously this is brilliant because she can still, you know, live her life.
40:49And that's exactly what we want.
40:51What I want to achieve is a significant difference for patients with brain cancer.
41:00You know, when I started in Cambridge in 2013, there were very few scientists who were doing work in this field.
41:08And now I think there are more.
41:10And that's what I want.
41:11I want us to build a village to try and cure this.
41:14That village includes consultant oncologist, Professor Juanita Lopez, who worked with Richard for three years to get the groundbreaking trial up and running.
41:27They're now finally starting to see the first patients benefit from their work.
41:33I saw Amanda in clinic recently.
41:37The tumour seems to be shrinking.
41:39So from my perspective, this looks really promising and I'm really excited.
41:44The other thing to say is that if she wasn't on this drug, not only would it not have shrunk, it would have increased in size.
41:51So actually, you know, seeing it shrink is really quite different to the natural history of what we'd expect this tumour to do in this scenario.
41:58This is David's scan. So we've removed all the tumour in his right temporal lobe, which is great.
42:04I think we're still waiting for the sequencing on him, but I've just checked and that should be back within the next week or so.
42:10So it'd be good to discuss to see whether he has any targets as well.
42:16You must remember I said, well, this is too big. This is too hard.
42:19It's challenging.
42:20It was too difficult. It was too hard to do.
42:24Yeah.
42:25You know, if someone was brave enough to do it, here it is.
42:28Yeah. And I think that you had great ambition.
42:30I had ambition.
42:32And I think by putting that together, we were able to be greater than the sum of its parts.
42:38There've been moments along the way where it's been exhausting.
42:44It's been floods of tears and chaos and crisis management.
42:51But if, you know, we're not going to do it, kind of who is?
42:54And they don't have a voice. And I think that's a really sad, you know, bit of the story that patients, they can't speak for themselves.
43:03So it's really, you know, championing those who, you know, have no voice.
43:08Or can't. Yeah.
43:12Where do we think this will take us?
43:15I think we want to cure brain cancer.
43:18Yeah. It's all there. We just need to link it together and have the ambition.
43:22Sky's the limit.
43:24The trial structure means that we can add new drugs as they come on board.
43:34And that gives us the opportunity to just keep adding to it, keep adding to it until we find a solution for every patient who has this problem.
43:45This clinical trial will last for as long as it needs to last.
43:48And we hope it's going to last for as long until we cure this cancer.
43:54The ultimate aim is to cure brain cancer.
43:56I think we have to be that ambitious.
43:57Now, we are a long way away from that.
43:59Okay. I'm optimistic, but I'm not stupid.
44:02We have a lot that we need to do, but we are on a trajectory.
44:06We are on the first step and the ladder.
44:08But we have to be ambitious. We have to be positive.
44:12We don't just want to improve how the cancer looks.
44:15We don't want to get people a few months.
44:17We want to change how we manage this cancer for good.
44:21But you have to start somewhere.
44:23And we're very much at the start of that journey.
44:25We have to go.
44:33Let's go.
44:39We're very much at it.
44:41Gracias por ver el video.
45:11Gracias por ver el video.
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