00:00It helps doctors see exactly where their instruments are,
00:06help deep inside the body, suffer surgery, more precision.
00:11Today, they bring on stage with a live demo on artificial tissue.
00:17Please welcome, Michele Diana from Astra.
00:22Nice!
00:23Hello, Michele.
00:25Thank you, thank you.
00:25How are you?
00:26Very well.
00:27You have something on your back.
00:28Yeah, I have something on my back.
00:29Oh my god.
00:31Yeah, hi everybody.
00:33Yeah, this is a fake column that we will use for a little demo.
00:38But maybe I first introduce myself a little bit and the company.
00:43So I'm Michele Diana, I'm a digestive surgeon.
00:48And I'm a translational scientist in surgical data science, robotics, and advanced imaging.
00:57So literally augmenting the senses that are required to perform precision surgery.
01:02So we operate with the hands, augmented with robotics.
01:05We see with the eyes, augmented with advanced imaging modalities.
01:09And of course, then what ties everything together is the brain.
01:14So surgical data science.
01:15So surgical data science.
01:16And with Astra Nice, we try to put all this together.
01:22So what we have developed is based on three pillars.
01:28So our core technology is a chemical compound, which we call internally Astra View.
01:35This is a polymer which expresses fluorescent properties.
01:45Fluorescence is the physical mechanism in which, upon illumination with a given wavelength, the compound will respond to a different
01:57wavelength.
01:58And this allows us to see through layers of tissue.
02:02Literally, we can make invisible things visible and you will have a real-time demonstration.
02:08A second pillar, of course, is software.
02:12We have a proprietary software that allows to compute the fluorescent signal and provide standardized data.
02:21And then we have also a little hardware that has been made by our R&D head.
02:31And this is the first, and so far only, portable and wireless near-infrared camera.
02:37So I'll just show you a couple of videos first.
02:43This is a study on the human specimen.
02:49What you will see here, this is a catheter that has been inserted into the ureter.
02:55So the ureter is the tube that connects the kidney to the bladder.
02:59And actually, this ureter can be injured during surgical procedures because the surgeon didn't see it.
03:06But obviously, I don't think that you need a randomized clinical trial to understand that if you can see it
03:11so beautifully,
03:13actually, the chances that you injure it are lower.
03:18And then, this is another application.
03:21This is a clip that a gastroenterologist will place near to the tumor.
03:27For example, in the colon, that's why we brought a colon model here.
03:30And this is in the stomach.
03:32So I'm sorry if a, this is surgical images, right?
03:36In real time.
03:38So I mean, in a minimally invasive.
03:40But that's a real thing.
03:41So you see, this is the stomach.
03:43The surgeon is spooling it.
03:45And you don't see what the clip is.
03:46But when you turn the near infrared on, then you will see it appearing through the tissues.
03:50And now, if we can move to the demonstration, please.
03:58So, we will first start with something very simple.
04:02Because there is no electronics.
04:04This is pure chemistry.
04:04So I just put a, literally, you can paint it.
04:08You can consider it as like a nail polish.
04:11So here we have a Eppendorf tube that we just painted a little bit on it.
04:16And let's simulate as this is a clip into a colon.
04:20So, I will go into the colon.
04:25Like a gastroenterologist.
04:28So, and everybody who is above 50, this is a cancer awareness period.
04:42So, so you see, look on the, on the left side, you have white light images.
04:49You see?
04:49And on the, sorry, on the left side, and on the right side, you have the Eppendorf that
04:55you are seeing through, trust me, this is a very thick tissue.
05:00And thanks to the fact that the, this is a meeting, this is responding to the excitation
05:07at a different wavelength.
05:09And we can go down to 1.3 centimeters.
05:12After I will do something funny for you.
05:14So, if we can move to another demonstration.
05:21We have some devices.
05:24Let's start with the clip.
05:26So this is a, this is the clip, endoscopic clip.
05:30The gastroenterologist will place this, uh, near to, next to a tumor.
05:38And you see how bright you can see on the right side, but this is not the, you don't appreciate
05:43this in the, in this case to appreciate.
05:48I will put the clip into this catheter.
05:52And you will see that this is on the left side, it will be completely invisible.
05:56And on the right side, you see the clip shining through it.
06:01And trust me, this is also pretty thick.
06:03And also see, it is very opaque.
06:06Um, and yeah, I mean, we have a different equipment here.
06:11Maybe we can show them all together.
06:13So we have a, uh, urinary catheter.
06:17We have PVC.
06:19We have some needles.
06:21Basically, we have surveyed 242 surgeons and found 60 relevant clinical applications.
06:27Um, just maybe, uh, uh, but we, we are not only in healthcare.
06:32We are also thinking about other applications in, uh, namely in, uh, cyber security counterfeiting.
06:41Uh, and just, I want you to appreciate something.
06:48Okay.
06:49Can you put the black one?
06:50So it's ham, uh, ham, literally ham.
06:54The closest thing I found to simulate, uh, tissue.
06:58I mean, uh, that's the muscles, right?
07:00So here you have, you see, uh, left side is white light.
07:06Right side is nearing friend.
07:08First slice of ham.
07:11You see, uh, I mean, this is pretty, this is pretty opaque, right?
07:15You don't see through it.
07:16Right.
07:16And you see, uh, upon illumination, you can, uh, see what's going on there.
07:22I mean, uh, you see the, the spot, put the second slice.
07:27You keep on seeing, put the third slice.
07:32I put the fourth slice.
07:36And actually you still can see where the signal is coming from, right?
07:40But the surgery is done all the reverse of what I'm doing here.
07:43So surgery is by dissection.
07:46So you discover it.
07:48So I'm doing it all the other way.
07:50You see, Oh, okay.
07:50I see something.
07:51It could be a lymph node, right?
07:53Let me, let me dig into it.
07:55And so I remove one layer.
07:57Oh, wow.
07:57I'm on the right path.
07:59So I remove another one.
08:01Yes.
08:01It's, it's coming.
08:03I remove another layer and here I am.
08:07So literally this is a GPS, a visual GPS for surgical applications.
08:13And as I was telling you, uh, I don't know how much time I've left.
08:18Um, but we are not only in healthcare.
08:20We are in everything that, uh, in which making invisible things visible through layers of tissue can be interesting.
08:25And for example, uh, can I show this already?
08:30So if someone wants to witness a, this is a completely white paper, right?
08:34There is nothing written on it.
08:36Well, everybody agrees.
08:38And, uh, yeah, that's what happens when it goes under near infrared light.
08:43So there is our logo.
08:44And eventually there is a, if you can scan it, it will be on our website.
08:52Thank you so much.
08:57Questions?
08:59Oh, Eric, maybe.
09:04Thank you so much.
09:06Mr. Dayan.
09:07Can we have a round of applause again?
09:10I'll let you go back with all your stuff.
09:13Yeah.
09:14Oh, this is, uh, yeah.
09:16It's a real one.
09:17It's inside.
09:17It looks very, it's very, I mean, this is a, a, what we used to train.
09:22Woo.
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