00:00Please welcome Dr. Laura Salisbury, CEO of Knits Region.
00:09Hello, Doctor.
00:23In just 10 minutes when I talk to you today, 120 lives will be entirely shattered by stroke.
00:33That's just 10 minutes.
00:35A massive 40% of those people will be told, sorry, there's nothing more that can be done for you.
00:43And they are excluded from the care pathway.
00:47They are dependent entirely upon loved ones, care and repeat appointments back and forth to support the rest of their
00:58life.
00:59And stroke is emerging at an earlier and earlier and earlier age.
01:06Those 40% are the people who we are here to help today.
01:13This is Peter.
01:14I met Peter about a year ago.
01:17He had a stroke at the age of just six years old.
01:22He lived for over four decades of his life without use of his hand and arm.
01:29Remarkably, he learned to walk again.
01:31But he was never able to re-assimilate back into everyday life because of limited use of his limb.
01:42Now, Peter entered our lab and said, Laura, do you know what?
01:46Actually, I know you can't help me because I'm too far gone.
01:51But I want to donate my data to science and to research.
01:54So we said, you know, come on in and let's see what we can do.
01:59Little did he know that after just four hours, flickers of movement would emerge in his hand and fingers.
02:11Movement after just four hours that he hadn't seen in over four decades.
02:17And he's not alone.
02:2032% of people who've walked through our doors have emerged with movement in their hand and fingers.
02:30We've increased the signal that travels from their brain, the motor cortex and subcortical regions back down to the paralyzed
02:37area by three times.
02:38And we've tripled the gold standard.
02:44We do this through a very simple device which I'm wearing today.
02:49A wrist worn device and a single ear foam.
02:54These two things designed to fit seamlessly into everyday life and worn on a daily basis can retrain the pathway.
03:06Let me show you how it works.
03:07So the wrist band itself delivers taps to the arm.
03:13And it's essentially poking you in the arm.
03:16But it's really, really powerful.
03:18It gives a powerful signal to the spinal cord.
03:23The click sound that's delivered through the earpiece is precisely time to pick up that neural signal from the spinal
03:30cord
03:30and force it through the brainstem to the primary motor cortex and back down again.
03:34And we do this millions and millions and millions of times over and over again.
03:39The more people are using this, the greater the gains that they have.
03:44Just plan.
03:45Here's another example.
03:51That was the before.
03:53This is after.
04:00we are significantly increasing movement through two very simple but very powerful stimuli
04:08and doing this through a pathway that has been notoriously under known and under researched
04:15the reticular spinal tract it remains entirely intact after stroke and brain injury
04:22so what people typically do is after this stroke they will be told you know what you need to go
04:28and
04:29see a physiotherapist and you need to build on that but they can't do anything for this 40 percent
04:33because they don't have that foundational level of movement to be able to build upon so they try
04:38their best but they're turned away we build that foundational layer of movement we start from the
04:44ground up by forcing signals through an entirely intact pathway typical processes our competitors
04:52are forcing signals through the corticospinal tract through the damaged tract we're doing things
04:59entirely differently we're doing things through the undamaged areas and we do that over and over and
05:06over again so your life is saved in hospital you're searching for a private physio you're too early
05:14we build that first movement and we sit with you throughout your entire care pathway to build
05:22strength and continue to support you this gives you the foundation layer of rehab
05:31this creates value across the entire system for us for patients who get the right level of treatment
05:39for the physios who can treat more people but also for clinics to increase their reach that 40 percent of
05:45the population but we're not just building a device we've got a strong data moat behind the reticular
05:54spinal tract and the potential that this can do now our treatment can do two really powerful things
06:02it can build strength but the way that we program the device we can also relax overactive painful
06:09muscles so often you see people coming in and they have a really tight clenched fist overactive and
06:16painful and causing them trouble often leading to amputation if it's so severe we can relax and open up the
06:23hand and then build the strength all by the way that we deliver the tap and the click and the
06:28order that
06:29we do so we're creating three data layers in this respect on a neurological basis physiological and
06:37behavioral in two main categories so we're not just looking at brain injury we are also recruiting
06:43healthy individuals and understanding how neuroplasticity works with this pathway in healthy
06:52which will ultimately lead us to looking at how we can implement this not just for stroke and brain
06:58injury but how we can build and maintain muscle mass in cases that you know have high levels of
07:05obesity where the rise of glp1 drugs are leading to the increased dire situation of muscle mass
07:13becoming a severe problem pairing this with glp1 agents you know can really have a powerful impact on
07:22the population before crisis even happens and this fits us at the center of three really converging
07:29markets neuromodulation which is the frontier of new neuroscience that's emerging it enables us to
07:39manipulate that neural system and modify it and tweak it so we can prime muscles we can understand how
07:46they work with the data that's coming in and we can modify that through very simple stimuli
07:53this is important as we face um really difficult emerging problems in the world an aging population
08:01stroke and brain injury doubling in the next five years
08:04and the rise of rapid weight loss um opportunities in the market who have no current real solution
08:15beyond some small drugs which could help them to maintain muscle mass and tone so this is a huge market
08:24we are in our team have um the world leaders in neuroscience and neurology based in central london
08:32and we have some fantastic regulatory support so we're on the cusp of launch with our device
08:42we've validated it and we are now looking for any potential partnerships people who would like
08:50to come and try this out for themselves so do reach out to me um thank you very much
09:08okay we have a minute for questions feel free to uh ask your questions
09:25thanks for your presentation uh i have a question once you actually start going into your let's call
09:32it therapy um do you actually need to wear the devices all the time during the rehabilitation or
09:39there is a moment that the second transmission pass is developed and you may take them off and it's
09:46going to work yeah and so we we advise that you wear this as long as possible because the greater
09:54the
09:55gains we've seen a difference between 30 to 50 percent in terms of the functional outcomes that could be
10:01gained from the amount of hours that are used with with this device but the the results are long
10:08lasting so we follow up with each individual patient when they take that device off the videos that i
10:13take that's with the device off and we follow up in the home setting and six months later and that
10:19gain
10:19is remaining for the rest of their life so they just need to continue to build upon that and sustain
10:27that recovery
10:34any more questions
10:38no more time for another question thank you dr thank you so so much can we have a round of
10:44applause again
10:45thank you
10:46you
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