Mild Head Trauma Reversed in Rats with Psilocybin Treatment

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00:00Mild head trauma reversed in rats with psilocybin treatment.

00:05A Northeastern University study found psilocybin may repair brain damage from head injuries.

00:10In treated rats, brain swelling decreased, neural connectivity improved, and dementia-linked

00:15proteins reduced compared to untreated rats.

00:22Psilocybin reduces inflammation, enhances neuroplasticity by binding serotonin receptors,

00:27modulating brain-derived neurotrophic factor, stabilizing blood-brain barrier, dissolving

00:32tau proteins, addressing chronic traumatic encephalopathy.

00:40Psilocybin significantly aids rat recovery from head injuries.

00:43By day 22, brain swelling reduced by 48%, tau proteins decreased 40%, suggesting a possible

00:50reboot effect.

00:53A 2024 study found a 25-milligram psilocybin dose disrupted cortical connectivity, aiding

01:01brain rewiring and promoting a weeks-long cognitive reset.

01:09Psilocybin may treat CTE by targeting tau proteins.

01:12Over 5 million Americans with traumatic brain injury disabilities risk dementia, underscoring

01:18therapy needs.

01:23Psilocybin presents challenges.

01:25Optimal dosing is vital as low doses boost neurogenesis, high doses inhibit it.

01:31Administering during acute injury can worsen inflammation, requiring structured therapy with

01:35cognitive rehabilitation.

01:41Psilocybin challenges neurology's pessimism by reducing inflammation, restoring synaptic plasticity,

01:47diminishing tau phosphorylation.