UCLA Discovers Groundbreaking Stroke Rehabilitation Drug That Reconnects Brain Pathways in Mice

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00:00UCLA discovers groundbreaking stroke,

00:03rehabilitation drug that reconnects brain pathways in mice.

00:08UCLA researchers have identified the first drug

00:11to reverse stroke-related movement loss in mice,

00:14offering new hope beyond rehab therapy.

00:20Dr. Carmichael says stroke rehab needs a breakthrough,

00:23a drug that mimics physical therapy,

00:25since most patients can't sustain intense rehab.

00:28Researchers found that after a stroke,

00:30brain cells far from the damage site disconnect,

00:33causing movement issues.

00:35They're now exploring drugs to mimic rehab effects.

00:41Researchers found that stroke disrupts gamma oscillations

00:44in parvalbumin neurons, vital for movement.

00:48Rehab restored these oscillations,

00:50and two drugs may replicate this effect.

00:53The drug DDL920 significantly improved movement control

00:57in mice by exciting parvalbumin neurons.

01:01This study identified key brain circuitry for rehab

01:04and a potential drug target,

01:05though human trials require further research.

01:12UCLA Health's breakthrough study has uncovered

01:14how physical rehab restores brain rhythms,

01:17and replicated it with the drug DDL920 in mice.

01:20This could revolutionize stroke recovery,

01:25offering more effective and accessible treatments,

01:27though further testing is needed for human safety.