00:03the brain is our body's control center and as such is very well protected obviously our skulls are
00:08the first line of defense but the blood-brain barrier is another way our brains are protected
00:13even against our own pharmaceuticals and that's a problem science alert reports that some 98
00:18percent of drugs can't enter the nervous system for that very reason that might be changing soon
00:23university of pennsylvania researchers say they have developed an analog blood-brain barrier in
00:28a lab and it's letting them test new ways of passing through it like never before they're
00:32testing what are called lipid nanoparticles fat soluble drugs which can carry with them other
00:36things including antibodies and rna messengers so far they've discovered five nanoparticles that
00:42are good candidates for carrying pharmaceuticals across the brain's protective barrier a huge
00:47breakthrough and one the researchers call an exciting proof of concept that will no doubt
00:51inform novel approaches to treating conditions like traumatic brain injury stroke and alzheimer's
00:57still there's much work to be done as a study also found that even though the nanoparticles
01:01were able to pass oftentimes the drugs never made it through with them
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