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**High bilirubin on your blood test?** Before assuming you have liver disease, there are a few important things you should understand about this common laboratory finding.

Bilirubin is a yellow pigment produced mainly when your body breaks down aging red blood cells. Your liver processes bilirubin and helps eliminate it through bile. However, when bilirubin accumulates in your bloodstream, it can sometimes signal an underlying medical condition.

But here's something that might surprise you: **Not everyone with elevated bilirubin has liver disease.** Some perfectly healthy individuals have mildly elevated bilirubin throughout their lives.

In this episode of *Candid Conversations with Dr. Kevin Lowe*, we explore the science behind bilirubin and what your laboratory results may be telling you.

**What you'll discover:**

- What bilirubin is and why your body produces it.
- The difference between direct and indirect bilirubin.
- Why liver disease, gallstones, and red blood cell destruction can raise bilirubin levels.
- How certain medications and alcohol-related liver injury affect bilirubin.
- Why Gilbert syndrome can cause elevated bilirubin in otherwise healthy people.
- What normal bilirubin levels look like.
- When high bilirubin deserves further medical investigation.

**Can bilirubin be high even when your other liver tests are normal?**

Absolutely. Gilbert syndrome is one possible explanation. This common inherited condition reduces the liver's ability to process bilirubin efficiently, resulting in mild elevations that are generally harmless.

However, bilirubin levels must be evaluated alongside other laboratory findings and clinical symptoms. Yellowing of the eyes or skin should always be medically assessed, particularly when accompanied by abdominal pain or fever.

**The takeaway:** High bilirubin is not necessarily a sign of liver damage. Understanding whether your direct or indirect bilirubin is elevated can provide valuable clues about its cause.

Join Dr. Kevin Lowe for another straightforward, evidence-based discussion designed to make medical information easier to understand.

**Medical Disclaimer:** This video is intended for educational purposes only and does not constitute individualized medical advice, diagnosis, or treatment.

#HighBilirubin #BilirubinBloodTest #LiverDisease #GilbertSyndrome #LiverHealth
Transcript
00:00Your blood test shows high bilirubin.
00:02Does that mean something is wrong with your liver?
00:05Not necessarily.
00:07In fact, some perfectly healthy people have elevated bilirubins throughout their lives.
00:15But in other cases, high bilirubin can be a warning sign of liver disease,
00:21blocked by ducts, or even the destruction of red blood cells.
00:26So how can you tell the difference?
00:29Well, the answer may lie in something called direct and indirect bilirubin.
00:36And in the next few minutes, I'll explain what those numbers mean and when you should be concerned.
00:44Now, bilirubin may sound like some mysterious chemical.
00:49But believe it or not, you see evidence of it every single day.
00:55It helps give your stool its brown color and your urine its yellow color.
01:02And if too much bilirubin builds up in your blood, you may actually see a yellow color in your eyes
01:09or skin.
01:11But where does it come from?
01:14Most bilirubin comes from old red blood cells.
01:18You see, red blood cells contain hemoglobin, the substance that carries oxygen around your body.
01:26When these cells become old, they are broken down, mainly in the spleen and liver.
01:32A part of their hemoglobin is converted into bilirubin, which then travels through the blood to the liver.
01:42While in the liver, the bilirubin undergoes further changes to make it soluble in water.
01:50This water-soluble form is called conjugated or direct bilirubin.
01:58The liver then releases this bilirubin into the bile, which carries it to the bowel.
02:04Some of this bile is temporarily stored in the gallbladder.
02:09So indirect or unconjugated bilirubin forms before it is processed in the liver.
02:17And direct or conjugated bilirubin forms after it is processed by the liver.
02:23But why does this matter, whether your bilirubin is direct or indirect?
02:29Because that difference can provide an important clue about what is happening inside your body.
02:37Bilirubin that is not processed by the liver is not soluble in water.
02:43And this difference can help doctors determine where certain illnesses are occurring.
02:51If your indirect bilirubin is high, your body may be producing too much bilirubin,
02:57or your liver may be having difficulty processing it.
03:01On the other hand, if your direct bilirubin is high,
03:06there may be a problem with the liver itself or with the normal flow of bile into the bowel.
03:13And here's another clue.
03:14Because direct bilirubin is water-soluble,
03:19it can sometimes pass into your urine and make it unusually dark.
03:25Indirect bilirubin cannot normally do that.
03:29In the same fashion,
03:31if both direct and indirect bilirubin are elevated,
03:35this may signify a problem taking place in the liver itself.
03:40Let us look at this more closely.
03:43Suppose you take a herbal preparation
03:46that causes your red blood cells to break down prematurely.
03:51Your unconjugated bilirubin may rise
03:54because your body is producing more bilirubin than the liver can process.
03:59When doctors see this,
04:02they will suspect there could be a problem with medications,
04:07herbs, or certain inherited conditions.
04:11On the other hand,
04:13if there is a gallstone blocking a major bile duct,
04:16there will be a rise in the conjugated bilirubin.
04:20This will direct doctors to perform imaging and other diagnostic testing
04:26to find what is obstructing the flow of bile.
04:31If you have inflammation of the liver,
04:34caused, for example, by viruses, medication, or alcohol,
04:39both the unconjugated and conjugated forms of bilirubin could be high.
04:45And this may prompt doctors
04:47to investigate whether the liver itself is damaged.
04:52Doctors may investigate whether you have viral hepatitis,
04:57liver injury associated with heavy alcohol use,
05:01or a reaction to medication.
05:04In severe cases,
05:06they may even consider poisoning from substances
05:09such as certain wild mushrooms.
05:11Your total bilirubin runs approximately
05:16from 0.1 to 1.2 mg per deciliter.
05:22Your indirect or unconjugated bilirubin
05:26runs approximately between 0.2 to 0.8 mg per deciliter.
05:32And your direct or conjugated bilirubin
05:36runs approximately 0.1 to 0.3 mg per deciliter.
05:41Here is something that might surprise you.
05:44Some perfectly healthy people have mildly elevated bilirubin
05:48because of inherited conditions like Gilbert's syndrome.
05:52Their liver processes bilirubin a little more slowly than usual.
05:58The condition is generally harmless and requires no treatment.
06:03So a mildly elevated bilirubin level
06:06does not automatically mean you have liver disease.
06:10Sometimes the explanation is a harmless inherited condition.
06:15But other times,
06:17high bilirubin may point to a problem
06:19with your liver,
06:20your bile ducts,
06:22or your red blood cells.
06:24And that's why doctors look at your direct
06:27and indirect bilirubin
06:30along with other blood tests
06:32to understand what is happening.
06:35If you notice yellowing of your skin or eyes,
06:39don't ignore it.
06:41Have it checked by a healthcare professional.
06:44And if you also have fever
06:46or significant abdominal pain,
06:49seek urgent medical attention.
06:52Remember,
06:54hibernurubin is a clue,
06:56not a diagnosis.
06:58What matters is understanding
07:00what that clue is telling you.
07:04I hope you found the video useful.
07:06If you did,
07:07like and share with your friends and family.
07:09You can support this channel
07:11by subscribing.
07:12Until the next video,
07:14stay healthy
07:14and stay safe.

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