00:00Your blood test shows high bilirubin.
00:02Does that mean something is wrong with your liver?
00:05Not necessarily.
00:07In fact, some perfectly healthy people have elevated bilirubins throughout their lives.
00:15But in other cases, high bilirubin can be a warning sign of liver disease,
00:21blocked by ducts, or even the destruction of red blood cells.
00:26So how can you tell the difference?
00:29Well, the answer may lie in something called direct and indirect bilirubin.
00:36And in the next few minutes, I'll explain what those numbers mean and when you should be concerned.
00:44Now, bilirubin may sound like some mysterious chemical.
00:49But believe it or not, you see evidence of it every single day.
00:55It helps give your stool its brown color and your urine its yellow color.
01:02And if too much bilirubin builds up in your blood, you may actually see a yellow color in your eyes
01:09or skin.
01:11But where does it come from?
01:14Most bilirubin comes from old red blood cells.
01:18You see, red blood cells contain hemoglobin, the substance that carries oxygen around your body.
01:26When these cells become old, they are broken down, mainly in the spleen and liver.
01:32A part of their hemoglobin is converted into bilirubin, which then travels through the blood to the liver.
01:42While in the liver, the bilirubin undergoes further changes to make it soluble in water.
01:50This water-soluble form is called conjugated or direct bilirubin.
01:58The liver then releases this bilirubin into the bile, which carries it to the bowel.
02:04Some of this bile is temporarily stored in the gallbladder.
02:09So indirect or unconjugated bilirubin forms before it is processed in the liver.
02:17And direct or conjugated bilirubin forms after it is processed by the liver.
02:23But why does this matter, whether your bilirubin is direct or indirect?
02:29Because that difference can provide an important clue about what is happening inside your body.
02:37Bilirubin that is not processed by the liver is not soluble in water.
02:43And this difference can help doctors determine where certain illnesses are occurring.
02:51If your indirect bilirubin is high, your body may be producing too much bilirubin,
02:57or your liver may be having difficulty processing it.
03:01On the other hand, if your direct bilirubin is high,
03:06there may be a problem with the liver itself or with the normal flow of bile into the bowel.
03:13And here's another clue.
03:14Because direct bilirubin is water-soluble,
03:19it can sometimes pass into your urine and make it unusually dark.
03:25Indirect bilirubin cannot normally do that.
03:29In the same fashion,
03:31if both direct and indirect bilirubin are elevated,
03:35this may signify a problem taking place in the liver itself.
03:40Let us look at this more closely.
03:43Suppose you take a herbal preparation
03:46that causes your red blood cells to break down prematurely.
03:51Your unconjugated bilirubin may rise
03:54because your body is producing more bilirubin than the liver can process.
03:59When doctors see this,
04:02they will suspect there could be a problem with medications,
04:07herbs, or certain inherited conditions.
04:11On the other hand,
04:13if there is a gallstone blocking a major bile duct,
04:16there will be a rise in the conjugated bilirubin.
04:20This will direct doctors to perform imaging and other diagnostic testing
04:26to find what is obstructing the flow of bile.
04:31If you have inflammation of the liver,
04:34caused, for example, by viruses, medication, or alcohol,
04:39both the unconjugated and conjugated forms of bilirubin could be high.
04:45And this may prompt doctors
04:47to investigate whether the liver itself is damaged.
04:52Doctors may investigate whether you have viral hepatitis,
04:57liver injury associated with heavy alcohol use,
05:01or a reaction to medication.
05:04In severe cases,
05:06they may even consider poisoning from substances
05:09such as certain wild mushrooms.
05:11Your total bilirubin runs approximately
05:16from 0.1 to 1.2 mg per deciliter.
05:22Your indirect or unconjugated bilirubin
05:26runs approximately between 0.2 to 0.8 mg per deciliter.
05:32And your direct or conjugated bilirubin
05:36runs approximately 0.1 to 0.3 mg per deciliter.
05:41Here is something that might surprise you.
05:44Some perfectly healthy people have mildly elevated bilirubin
05:48because of inherited conditions like Gilbert's syndrome.
05:52Their liver processes bilirubin a little more slowly than usual.
05:58The condition is generally harmless and requires no treatment.
06:03So a mildly elevated bilirubin level
06:06does not automatically mean you have liver disease.
06:10Sometimes the explanation is a harmless inherited condition.
06:15But other times,
06:17high bilirubin may point to a problem
06:19with your liver,
06:20your bile ducts,
06:22or your red blood cells.
06:24And that's why doctors look at your direct
06:27and indirect bilirubin
06:30along with other blood tests
06:32to understand what is happening.
06:35If you notice yellowing of your skin or eyes,
06:39don't ignore it.
06:41Have it checked by a healthcare professional.
06:44And if you also have fever
06:46or significant abdominal pain,
06:49seek urgent medical attention.
06:52Remember,
06:54hibernurubin is a clue,
06:56not a diagnosis.
06:58What matters is understanding
07:00what that clue is telling you.
07:04I hope you found the video useful.
07:06If you did,
07:07like and share with your friends and family.
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07:12Until the next video,
07:14stay healthy
07:14and stay safe.