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  • 9 minutes ago
Scientists from the University at Buffalo have crafted an injectable hydrogel aimed at enhancing drug administration for osteoarthritis. This novel platform establishes a lubricating semi-solid reservoir within a joint following a single, minimally invasive injection, facilitating the gradual release of medication from drug-loaded nanocarriers over several weeks. Validation of this system has been conducted with a SIRT6 activator, specifically intended to transport therapies that are poorly soluble in water. Researchers assert that it could merge prolonged drug delivery with joint lubrication, potentially minimizing the need for repeated injections and systemic adverse effects. Further advancements and clinical evaluations are essential to assess its effectiveness in patients.

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00:00Researchers in New York have developed a new approach to treating osteoarthritis.
00:04The injectable hydrogel is designed to deliver medicine directly inside an affected joint.
00:09After injection, the liquid quickly forms a semi-solid depot at body temperature.
00:14This helps keep drug-loaded particles inside the joint for several weeks.
00:18Researchers at the University at Buffalo developed the platform.
00:22It can carry poorly water-soluble drugs that are difficult to deliver effectively.
00:27The system has been tested using a SIRT-6 activator.
00:30That compound targets biological processes linked to osteoarthritis progression.
00:35The hydrogel also works as a lubricant, helping support joint movement.
00:40Researchers say this could reduce the need for repeated injections.
00:43It may also help limit exposure to medication throughout the body.
00:47But further research and clinical testing are needed before the technology can reach patients.
00:52Disclosure, this video contains stock footage and content created or enhanced using AI-assisted tools.
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