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  • 2 days ago
Scientists from the University of Chicago have modified a variant of Bifidobacterium longum, a probiotic bacterium naturally occurring in the digestive system and yogurt, to penetrate pancreatic tumors and function as a drug-producing entity targeting these growths. In experiments with animals, the modified strain, named BifidoSumIL-2, effectively delivered an immune-boosting protein directly into tumors, activating T cells that fight cancer and reducing the growth of pancreatic tumors. The most significant impact was observed when this method was used alongside chemotherapy, radiation, or immunotherapy. Historically, pancreatic cancer has been resistant to immunotherapy due to the tumors creating an inhospitable.
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00:00Scientists just turned probiotic bacteria into microscopic drug factories that hunt down cancer.
00:06Researchers at the University of Chicago engineered a strain of Bifidobacterium longum,
00:11a probiotic naturally found in the gut, and even in yogurt, so it seeks out and infiltrates
00:17pancreatic tumors. Once inside, the bacteria produce an immune-stimulating protein directly
00:23at the tumor site, switching on cancer-fighting T-cells right where they're needed.
00:27In animal studies, this approach slowed pancreatic tumor growth, and the effect got even stronger
00:33when combined with chemotherapy, radiation, or immunotherapy. That matters because pancreatic
00:39cancer has been notoriously resistant to immunotherapy, since these tumors create a
00:44cold environment that blocks immune cells from attacking. By turning a common gut bacterium
00:49into a targeted delivery system, researchers may have found a way to finally break through that
00:54defense. Disclosure, this video contains stock footage and content created or enhanced using
00:59AI-assisted tools.
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