Scientists at Scripps Research have made a game-changing discovery in the fight against cancer. They’ve uncovered how some tumors survive severe DNA damage using a backup repair method called break-induced replication (BIR). It’s fast but error-prone—and now, researchers believe this could be cancer’s hidden Achilles’ heel.
The key lies in a protein called SETX. When it’s missing, cancer cells build up dangerous R-loops in their DNA and become completely dependent on BIR to survive. By targeting BIR-related proteins like PIF1, RAD52, and XPF, scientists may be able to selectively destroy cancer cells—without harming healthy ones.
This could open the door to powerful new cancer treatments that exploit a tumor’s own survival strategy against it.
Watch now to learn how a tiny flaw could lead to a major breakthrough in cancer therapy. WooGlobe Ref : WGA276726 For licensing and to use this video, please email licensing@wooglobe.com
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