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Cornell Women's Heart Director on Improving Detection of Aortic Aneurysms
Bloomberg
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3 days ago
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00:00
When it comes to heart disease, whether it's men or women, it's such a big problem here in the U.S.,
00:05
the number one killer and cause of death for both men and women. What is it? Our diet, lack of
00:10
exercise, all of the above? What? Absolutely. And you have to think about other things as well.
00:15
You know, you pointed out really nicely that young individuals can also be affected. And I think it
00:20
goes to show that we really need to know a lot of things about our health. We really need to know
00:24
our numbers. We need to know what our blood pressure is early. We need to know what our
00:27
cholesterol is. We need to know what our blood sugar is. And certainly young people may have
00:31
other genetic conditions. And it's important to know what those genetic conditions are.
00:35
So you're focusing on something called an aorta aneurysm. I've heard of brain aneurysms.
00:40
What is an aorta aneurysm? It's a great question. You know, the aorta very recently, just in 2024,
00:46
was it's identified as its own organ and very rightly and deservedly so. So it's the largest
00:50
artery of our body. It attaches to the heart. It's actually shaped like a candy cane and it takes blood,
00:55
it pumps blood that's pumped from the heart and it actually transfers it all the way to all the
00:59
organs of our body, the head, the neck, the heart itself, the liver, the intestines, the spleen,
01:04
the kidney, the leg. So it's critical for our sustenance so much so that there are physicians
01:09
such as myself, cardiologists, surgeons that really dedicate their lives in caring for individuals who
01:15
have problems with the aorta. And one of those problems is an aneurysm. And an aneurysm is
01:21
essentially a dilation or bulging of that aortic wall. And so it's a little bit distinct from brain
01:26
aneurysm in terms of its location, but there are individuals with aortic aneurysms that can have
01:31
brain aneurysms and vice versa. So you've got actually an NIH funded study that you are doing.
01:37
Tell us a little bit about that. Yeah, absolutely. And nice to hear that you're getting money and
01:42
continue to get money from the NIH. Thank you. We actually recently got it. So I'm very,
01:46
very grateful for such a milestone. You know, when individuals have aneurysms, once they really
01:51
increase in size, dangerous complications can occur. And what do I mean by that? You know,
01:56
you think of a balloon as it gets bigger and bigger, a balloon can burst the aorta. As it gets
01:59
bigger and bigger, you can have a tear in the aorta. So now we have life saving procedures,
02:04
aortic surgery that can be pursued to prevent these complications that occur. I think it goes with
02:09
the theme. We want to be proactive rather than reactive. And so what our grant looks at is it combines
02:15
imaging, advanced imaging and genetics to really figure out how individuals with aortic conditions
02:21
do through time, especially those who've had that aortic surgery. So, I mean, I'm just hearing about
02:27
this for the first time, aorta aneurysm. Are there symptoms? Is it the kind of situation where you
02:32
don't know it until it happens? Because I know some of the brain aneurysms can happen in a snap.
02:37
Yeah, absolutely. Yes, it is. I mean, you can have large aortic aneurysms and you may not know that
02:42
you have one until something catastrophic occurs. I think there is a positive outlook on aspects of
02:49
this. Now provider awareness is going up. Now we're doing imaging for unrelated reasons. People are
02:54
getting scans for prevention-based readings. Now we're taking very intricate family histories. Yeah,
03:00
you were going to say something. Well, we're talking with Dr. Nupur Narula. She's director of the
03:03
Women's Heart Program at Weill Cornell Medicine. It was so funny. I'm trying to think who did a story,
03:07
whether it was the Times, whether it was us. But it was just this idea. If you go to, is it Korea?
03:13
You can get scan head to toe every year. What a brilliant idea. I don't know if our insurance
03:19
companies would like that very much. Well, that's it. And it's a lot less expensive,
03:22
but it's such a great preventative kind of way to go about it. And of like any kind of early
03:27
problems that are out there. Why aren't we doing it? Is it just because it's so expensive here in the
03:31
U.S.? It's expensive. And so I think that there's... And why is it so expensive? Because if we were all
03:36
getting it, the frequency, I don't know. It's a really good question. I think the more we scan,
03:41
the more we find. You can find things that may not matter, but we'll go down roads of testing.
03:46
Right. Right. So I think that it goes to highlight a couple of things. Family histories, taking them
03:50
from our family is free, right? Ask your family, have they had any sort of issues with the aorta? Has the
03:56
aortic size been measured? Have they had any sort of prevention test? Did the aortic size come up in that
04:00
test? Did anybody die suddenly in the family? If they did, was an autopsy done? You know,
04:05
you can ask several questions to figure out what the cause of the passing was. So these are ways to
04:10
screen. And then I always say, participate in research studies if you have the ability to do
04:14
so, because I think involvement in studies and women's involvement in studies is really,
04:19
really critical. That's a really good point. And you know, sometimes you go to the doctor. I've
04:21
been asked you, would you like to participate? I think the first instinct says, no, no, no, no,
04:25
thank you. But it really can help science overall in general for years to come.
04:29
Absolutely. And the more science we do, the more sex specific, college, but that's because I got
04:33
paid. And some studies will still pay actually, you know, depending on what you do. But I think
04:39
the participating in this allows us to also come up with sex specific differences that have, you know,
04:45
impact on behavior. Well, let's go. Yeah, let's go another layer down because you specifically are
04:50
focusing too on pregnant women. Yes. Why? So I think pregnancy is a very delicate time in our lives,
04:57
right? There's several changes that happen. Your heart rate changes. It goes up. The blood
05:00
pressure goes down initially, but in the later stages of pregnancy, your blood pressure rises,
05:05
including after pregnancy, the cardiac output, the pump, the efficiency of our heart goes up because
05:10
we're supplying blood to ourself, but also the placenta. And then you have all the hormonal changes
05:14
that occur, estrogen, progesterone, and these can actually change the microstructure of the wall.
05:19
So if you think of women who already have underlying aneurysms, and then you add in all of these
05:24
changes, these women are in a more vulnerable state. So I think understanding what they have,
05:29
their condition, instituting appropriate surveillance, and thereby appropriate management
05:35
allows us to take women through pregnancy safely. Your advice to maybe a pregnant woman hearing this
05:40
or someone who has a pregnant person in their life and they want to be proactive. What's your advice
05:44
to them? Know your numbers. Really know your numbers. Know all of your numbers. We very rightly talk
05:49
about blood pressure, cholesterol, blood sugar. You should also know if you've had a scan, what
05:54
is the aortic size? And also know your family history. Two big things to take away. We always
05:58
need to be proactive rather than reactive in as many ways as we can. Is it more likely for a pregnant
06:03
woman to have an aortic aneurysm? So it's not that the pregnancy will cause the aneurysm. It's that
06:10
a woman may have an aneurysm and during pregnancy, it is possible that that aneurysm may grow a little bit
06:16
in size. Okay. I also, before we let you go, uh, I was reading an article recently in the times
06:21
about the signs of a heart attack and they're not always the outward, Oh, I'm holding my chest,
06:26
you know, shortness of breath. And there was one doctor who did some research in India
06:30
who was saying, you know, it could, if you look at blood pressure through the years,
06:34
if your blood pressure seems to oscillate a lot, that could be a signal. Is that true?
06:39
You know, I mean, I think, listen, I think anybody can have any sort of manifestation,
06:44
right? So when you even think about blood pressure, in what environment are we measuring
06:47
our blood pressure? Is it at home? Is it in the doctor's office? So certainly, you know,
06:51
there are changes in blood pressure, changes in heart rate, and then there are symptoms,
06:55
but there can be atypical symptoms, not the classic symptoms that we see. And so I think
06:59
if anything feels unusual, bring that to your provider. That's your time to really talk about it.
07:04
Oh, okay.
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