How an Imbalance in Bacteria Might Influence Multiple Sclerosis and Predict Its Severity

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00:00How an imbalance in bacteria might influence multiple sclerosis and predict its severity.

00:06Multiple sclerosis is an autoimmune disease damaging myelin in the central nervous system.

00:12It affects over 1 million people globally, with nearly a third of cases in the United States, highlighting its widespread impact.

00:23Multiple sclerosis risk factors include genetics.

00:27In addition to certain environmental factors, such as gut health, diet, and infectious diseases.

00:36A new study has also revealed a link between bacterial imbalance and multiple sclerosis risk.

00:43Researchers have suspected that a person's gut bacteria could potentially influence their multiple sclerosis risk.

00:50Associate Professor Ashutosh Mangalam's team used patient samples and lab experiments.

00:57to find that the ratio of two gut bacteria can predict multiple sclerosis severity, emphasizing the microbiome's role in disease prevention.

01:06Analysis showed Blaudia was more prevalent in MS patients, while Prevotella was less common.

01:12Mouse experiments revealed the balance between Ackermansia and Bifetobacteria is crucial in distinguishing mice with MS from those without.

01:21Researchers found increased Ackermansia and decreased Bifetobacterium in mice with MS-like symptoms.

01:28Mice given Blaudia showed worse symptoms, suggesting bacterial imbalance influences multiple sclerosis severity.

01:36Researchers found increased Ackermansia and decreased Bifetobacterium levels in MS-affected mice.

01:42This imbalance also appeared in human MS patients, suggesting a potential diagnostic marker and influence on disease severity.

01:52Further studies could enhance diagnosis and treatment options.

01:56Ackermansia and Bifetobacterium levels in MS-like symptoms.

01:58Ackermansia and Bifetobacterium levels in MS-like symptoms.

01:59Ackermansia and Bifetobacterium levels in MS-like symptoms.

02:00Ackermansia and Bifetobacterium levels in MS-like symptoms.

02:01Ackermansia and Bifetobacterium levels in MS-like symptoms.

02:03Ackermansia and Bifetobacterium levels in MS-like symptoms.

02:05Ackermansia and Bifetobacterium levels in MS-like symptoms.

02:06Ackermansia and Bifetobacterium levels in MS-like symptoms.

02:07Ackermansia and Bifetobacterium levels in MS-like symptoms.

02:08Ackermansia and Bifetobacterium levels in MS-like symptoms.