How to Reduce Toxic Tau Protein and Lower Alzheimer’s Risk

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00:00How to Reduce Toxic Tau Protein and Lower Alzheimer's Risk

00:03Alzheimer's disease, a prevalent brain disorder, affects millions globally

00:08and is notoriously difficult to treat, complicating neurodegenerative disease management.

00:18Glutamate promotes toxic tau buildup linked to Alzheimer's,

00:21but USC's stem cell research offers a new method to remove these proteins

00:30Researchers enhance tau clearance to prevent harm as tau stabilizes brain cells

00:35but malfunctions disrupt Alzheimer's management.

00:39Neurofibrillary tangles form by clumping together, blocking neuron communication,

00:44leading to memory loss and cognitive deficits in Alzheimer's patients.

00:51Researchers initially targeted beta amyloid, but studies reveal tau's critical role in Alzheimer's.

00:57Strategies include clearing toxic tau and preventing buildup.

01:01USC stem cell researchers studied Alzheimer's treatments with lab-grown brain structures in mice,

01:07discovering high glutamate levels increase tau buildup and nerve cell death.

01:14USC researchers found suppressing gene KCTD-20 prevents tau buildup,

01:20activates lysosomes, aiding in cell cleanup and protection.

01:27Lysosomes remove toxic tau from organoid cells.

01:31Study lead Jesse Lay noted their focus on expelling tau proteins rather than limiting glutamate activity.

01:38Type 2 targets tau damage aiding Alzheimer's treatment.

01:42Blocking it in mice reduced toxic tau.

01:45But brain efficacy, unconfirmed.

01:49A vaccine, AADVAC1, trains the immune system against toxic tau proteins.

01:56Researchers explore treatments reducing tau phosphorylation

01:59and enhancing lysosomal clearance to counteract tau toxicity.

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