A recent study conducted at the State University of Campinas in Brazil investigated the process of muscle pain chronicity

Wend Wellness

They identified one of the mechanisms by which exercise prevents the transition from acute to chronic pain, protecting the body from inflammation and persistent pain.  Activation of the P2X4 signaling pathway in macrophages triggers the chronicity of inflammatory muscle pain.  Exercise prevents activation of this pathway, hence helping to prevent acute muscle pain from becoming chronic.  In general, exercise reduces pain by: * Promoting the release of happy chemicals like endorphins & serotonin and improving mood. * Improving circulation. * Reducing inflammation. * Building muscle strength to reduce pressure on joints. * Enhancing joint lubrication.  General Joint structure From internal to external a joint typically contains: -Articulate cartilage surfacing the articulating bones. -Synovial fluid. -Synovial membrane. -Joint capsule. -Ligaments. -Tendons.  How is synovial fluid produced? Synovial fluid is produced when ultrafiltrate (primarily composed of collagen, hyaluronic acid, lubricin, & prostaglandins (a hormone-like fatty acid)), produced by blood vessels lining the joint capsule, is pushed through the synovial membrane into the joint.  Synovial fluid lubricates and nourishes the articulate cartilage.  Exercises improves movement and circulation of synovial fluid within the joint. This lubricates the joints, enhances nutrient delivery, & waste removal, improving overall joint health.  #musclepain #musclepains #musclepainrelief #painrelief #painreliefproducts #painreliefnaturally #wendwellness

Transcript

00:00This is super, super cool. If you are somebody that's had muscle pain, you've

00:08had muscle pain for a while, what makes somebody have muscle pain for a long

00:15time? What makes it chronic? If you have acute muscle pain or that that lasts

00:19only a few days, how does it become chronic? How does this process of

00:25chronicity, we could say, occur? Well, they investigated just that at a recent

00:33study that they did at the University of Campinas in Brazil, or Campinas,

00:41however you say it. I didn't see an accent mark, I think Campinas. And they

00:45wanted to see the mechanism by which this happens. How does that acute muscle pain

00:50become chronic? Well, there are many different mechanisms involved, but they

00:57found one novel one. And it involves macrophages. What are macrophages? Well,

01:05they are immune cells that go to the site of injury, right? Or when there's muscle

01:09damage, they go there. When people are sick, things like that. And they can eat

01:14away debris, right? When the alarms are on, it sends a bunch of macrophages there and

01:18they take care of some problems. And there's a lot of other immune cells, of

01:21course, and things involved in an inflammatory response, right? And when we

01:26think of pain, we think of inflammation. The two go hand in hand, right? So the P2X4

01:34signaling pathway, the name doesn't matter, in these macrophages is responsible, at

01:41least one thing, one mechanism by which that acute pain, that acute muscle pain becomes

01:48chronic muscle pain. And they found something that can deactivate that pathway. That is

01:55natural. That is really cheap. At least in terms of money, it's free, really. It takes

02:04a lot of effort. Doesn't take a crazy amount of it to deactivate the pathway, but it takes

02:11some. Maybe you guys can guess what it is, right? Well, it's exercise. Here's another

02:17reason to exercise, you guys. P2X4 signaling pathway macrophages deactivates them, right?

02:25And so it helps to put that process to a halt, right? It doesn't let that acute muscle pain

02:32become chronic. And when we think of exercise, how does it reduce pain in general? Because

02:40we know that that is definitely the case. We've talked about trials where they showed a bunch of

02:45osteoarthritis patients, right? Joint degeneration arthritis, as you guys know, common arthritis where

02:51there's, you know, the cartilage is wearing away and whatnot, where these people, they would either

02:56exercise for three days a week and not like crazy intense. You're talking 40 to 70% of their max

03:03heart rate, just three days. Or they took ibuprofen every day. And it was like 600 milligrams, I

03:08believe, for a month. At the end of the month, the group that had greater reductions in pain,

03:13it was the exercise group. The ibuprofen didn't do anything long-term. No surprise there. It's band-aid.

03:19Okay. So how is exercise doing this? Well, we know that exercise reduces inflammation.

03:28That is well known. And reducing inflammation is going to definitely help with pain.

03:32So that's a good thing, right? And you can also reduce inflammation by eating healthy foods and all

03:36that stuff. We can talk about that. But it reduces inflammation, improves circulation. All right,

03:41improving blood flow. That seems like a good thing. Getting some blood pumping, right? Helping

03:47to promote the release of happy chemicals, like serotonin, for example. Your happy hormone

03:54slash neurotransmitter or brain chemical. Endorphins, things that make you feel good,

04:01puts you in a good mood. So of course you'll be in less pain. You're in less pain when you're in a

04:04good mood. It seems like that. It strengthens the muscles that surround your joints. So if my muscles

04:12are really strong that are supporting my joints, well, then my joints are going to be able

04:17to function better. And they'll be able to endure the same load more easily and they won't be as

04:23stressed. So it reduces pain in that way. But one really interesting way also is joint lubrication.

04:34So joint lubrication. So how does this, how does exercise help to lubricate your joints?

04:40Let's first talk about a joint. Let's, let's go through some very simple anatomy here. Two bones.

04:47Okay. See, these are our leg bones, right? It's our tibia, the one, the lower one. And this is the

04:52femur, the big one up here beneath the quad, right? And so can you just have the bones hitting each

04:59other? Well, that wouldn't be smart, right? So the body's a lot smarter than that. So it has what we

05:02call articular cartilage. It's like a cap on each one. All right. So now you got a cushion in the knee.

05:08That happens to be a meniscus also, right? Mediolateral, you know, we're going to talk about

05:12that. We have this cartilage on the bones. Now in between them, we have synovial fluid,

05:19right? So we have this fluid and it lubricates the joints. The fluid also helps to nourish the

05:26cartilage, right? It delivers nutrition to the cartilage to keep it nice and thick and healthy,

05:31help prevent it from wearing away.

05:32It supports waste removal from the cartilage. So we need to, and the joint itself, we need

05:41to remove waste in there too, right? So the fluid does a lot of good stuff. But is stagnant

05:47fluid a good thing? What happens when there's stagnant water in your pool, right? Mosquitoes

05:52start to lay eggs and all this stuff goes wrong, right? What happens when your blood flow becomes

05:58static? Things start to clog up, doesn't quite work as well. What happens when you don't start

06:02your car for a while? For years? It's not going to run the same. Maybe it won't even start,

06:08right? You got to keep things pumping. In general, that is true for health and for how machines

06:16operate. And we are a biological machine. So what do we have aside from this, right? Bones,

06:24cartilage, fluid, is that fluid just all over the place? No. Synovial membrane, encasing

06:30it. If the bones were here and here, picture they're still there because I have only two

06:34hands, arms. There's something here that is a fluid-like membrane that directly surrounds

06:41that fluid. We call that the synovial membrane, or the synovium, you could say. Now what's outside

06:49that is a thicker membrane? We call this the joint capsule. This is more fibrous. It's kind

06:55of like a bandage, right? So picture like a thicker type of thing, less elastic, you could

07:01say, surrounding the synovial membrane. And then outside that, and you have the bursa,

07:05and you have, you know, ligaments attaching bone to bone, and tendons attaching muscle to

07:09bone, all that stuff. But how is the fluid in the joint made in the first place? And do we

07:16stop making it when we're kids? No, you're making it throughout life. That process could

07:21slow down at some point. But we are making that fluid almost constantly. And the way we

07:28do it is we have these little blood vessels in the joint capsule. And they release what's

07:36called ultrafiltrate. It's just a fancy word for collagen and hyaluronic acid, prostaglandins.

07:45They're just fatty acids, like little fats in the body, right? Lubricant, you know, these

07:51are all things, the name precedes it, right? Helps to promote the production of something

07:55that lubricates joints, right? I love when there's a name like that. So it is made of

08:00that stuff, right? Is this thing that is coming out of blood vessels in the joint capsule, this

08:07ultrafiltrate. And then it goes from the joint capsule, gets squeezed out of there, and it

08:12goes through the synovial membrane, and it enters into that fluidy area, right? And that

08:19is how synovial fluid is produced. And it's produced. So is exercise producing more of this?

08:25Well, not necessarily. But it's doing one very important thing. Again, that stagnant fluid

08:32is not a good thing in general. And this exercise is helping it to move in the joint around that

08:42cartilage and to circulate. And if it's moving and circulating, then it can nourish the cartilage

08:49better, right? It can lubricate it, of course. It can help to eliminate waste. And so exercise,

08:57aside from deactivating that P2X4 macrophage pathway, is just so good for your joints. And it is so

09:06effective at reducing not only joint pain, but also muscle pain, as they showed in this trial. So

09:16really, really interesting stuff, you know? And again, I try to give you guys 100 billion reasons

09:22to do healthy stuff. This is another one. Go exercise, even if it means going for a walk every

09:28day or whatever. Go do something. We are meant to move, baby. That is for damn sure. Who do we got

09:36on here? Let's say what's up. It's going to get dark soon, so we got to go inside. It's raining,

09:41but under a tree's working out. And it's nice. I wanted to come out here. Ronald, how you doing?

09:47Ben Gomez. Adrian Martinez. Paul, what's up, dude? Maybe I'll see you tomorrow, man. Saladin,

09:56Ricardo, Sivia, Ash, what's up, baby girl? Life Wrangler, and Antonio. Appreciate the love.

10:03As for now, that's all we got for you, folks. We'll see you tomorrow, baby. Not sure where,

10:06not sure when, but we'll see you then. Have an awesome rest of your night. Thank you so much.

10:11Happy Friday. Happy Wind Wellness. See ya. These are fun.

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