- 2 minutes ago
The cast of Best Medicine offers a first look at Season 2, where Dr. Best attempts to conquer one of his biggest fears while his will-they-won’t-they relationship with Louisa keeps getting more complicated. And then there’s the rather unexpected question of whether mermaids might actually be real.
Best Medicine follows Dr. Martin Best as he adjusts to life and medicine in a quirky seaside community. Season 2 brings more unusual situations, complicated relationships and mysteries for the doctor to navigate.
Best Medicine Season 2 premieres September 22, 2026 on FOX and streams the next day on Hulu.
Best Medicine follows Dr. Martin Best as he adjusts to life and medicine in a quirky seaside community. Season 2 brings more unusual situations, complicated relationships and mysteries for the doctor to navigate.
Best Medicine Season 2 premieres September 22, 2026 on FOX and streams the next day on Hulu.
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00:01I'm looking great.
00:03Do you mind if I see how this looks, brother?
00:04Abigail, take one.
00:06Best medicine, season two.
00:07Oh.
00:09It's the best.
00:13When we first meet Martin in season two,
00:15he's got a lot going on.
00:16He is still our local town doctor.
00:19And Doc has a blood phobia,
00:21which is really hard to deal with.
00:22He doesn't want it being held over his head anymore.
00:24Very early on in the season,
00:25there is a moment where it feels right to tell the town,
00:28I have a blood phobia.
00:30And now my entire medical career is in jeopardy.
00:32We'll see what happens with that.
00:34This season, you know, Eden is back in town.
00:37She's now going back and forth between Boston and Fort Wend
00:40because of Louisa's IVF journey.
00:42And her and Martin are together.
00:45What?
00:45She's rearranged his office
00:47and I think rubbed a lot of the town the wrong way.
00:50Let the fun begin.
00:52They certainly don't like what she's brought back out in Martin.
00:55I don't have time for your nonsense right now.
00:57I'm a doctor and I'm trying to save a life.
00:59Dr. Best sucks!
01:00They obviously have medicine in common.
01:02They have a history together.
01:04We're going to get you over this blood phobia, okay?
01:07We're going to get you back to Boston
01:09so you can get the respect you deserve, okay?
01:11Exactly.
01:11I think there is a connection there,
01:13but it always feels like it's slightly missing.
01:15This weekend, it was nice.
01:20It was?
01:21Mm-hmm.
01:22I think his connection to Louisa is a big part of it.
01:24I was sure that Louisa and Martin were going to be together.
01:29That's what we hope to go on the journey of
01:31will they, won't they, watching two people
01:33to see what will happen.
01:37Yep.
01:37We're going to have to amputate from the neck up.
01:39What?
01:40There's some really interesting quirky medical cases this year.
01:44I've seen a lot of things in my day.
01:47Mermaids might be real.
01:49Whoa.
01:49They're so beautiful.
01:50I got Tourette's and poison ivy.
01:53We have three positive pregnancy tests and they're all men?
01:57Hey, but why are you both going ooh?
01:59Not sure. It just felt like something I was supposed to do.
02:01Me too.
02:01You're going to get more crazy events in Port Wendt.
02:04So many things go off the rails.
02:07Ah!
02:07We've got karaoke night.
02:09Yes, please.
02:11No one!
02:13We have a lobster crate race.
02:16We have...
02:17No more smoking.
02:19That darn Andrea Martin.
02:21What do you think, I am a moron?
02:22Absolutely 100% yes.
02:24If he says how much he dislikes the people,
02:26why does he stay here?
02:27He is Port Wendt through and through.
02:29And there is his blood phobia.
02:31If he's able to conquer that, we might lose him.
02:35What's beautiful about season two is now we know all the characters.
02:38Their relationships, the dynamics.
02:41You get to see these familiar faces that have made you laugh,
02:43that have made you cry.
02:44People who care about each other.
02:46You're one of us and you belong here.
02:49Stop with the oohing.
02:50There's no reason to oo.
02:52Stories about community.
02:54And the grounded moments.
02:56I think that's the kind of place that we'd all like to live in.
02:59Put life aside for a little bit and watch the people in this town.
03:02Because it's part of the fun of it.
03:03Well, it is our plans, but for years he's still a person for all these couple of years.
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