Breakthrough Study Uncovers Previously Unknown Cause of Parkinson’s Disease

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00:00Breakthrough study uncovers previously unknown cause of Parkinson's disease.

00:06Parkinson's disease, a neurodegenerative disorder affecting the nervous system,

00:10manifests subtly with tremors, stiffness, and balance issues. Though incurable,

00:15it is manageable with medication. Scientists recently identified a new cause,

00:21marking a significant breakthrough.

00:22For decades, Pink One's connection to Parkinson's was known, but its activation remained unseen.

00:33Australian researchers revealed Pink One's structure and mitochondrial bonding,

00:38marking a breakthrough. Parkinson's has 40 symptoms, impacting 153,000 in Great Britain.

00:44Management includes physiotherapy, medication, and surgery.

00:48In Parkinson's, brain cell turnover is slow, impacting disease progression.

00:58Damaged mitochondria stop energy production and release toxins, usually removed via metophagy.

01:04With Pink One mutations, this fails, causing cell death. High-energy brain cells are vulnerable.

01:11Pink One, linked to early onset Parkinson's in under 50s, operates in four steps,

01:17detecting mitochondrial damage, then binding to mitochondria, and Parkinson for recycling.

01:26Dr. Sylvie Caligari noted, this is the first observation of human Pink One

01:30attached to damaged mitochondria, revealing proteins that form the docking site. Mutations affecting

01:37Pink One in Parkinson's patients were also observed. With Pink One's structure known,

01:42It's now a viable drug therapy target.

01:55Dr. Sylvie Caligari mentioned, we started in airborne water because it was actually an

02:04antibiotic withרא realize that Maribussia delgokersoth is not restricted to the galaxies.