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00:00Could an FDA-approved Parkinson's treatment already exist? New findings suggest so.
00:07Parkinson's remains an incurable neurodegenerative disease.
00:11Typical symptoms include speech, balance, and motor challenges.
00:16Advanced stages worsen these issues, but it's possible that an existing FDA-approved treatment could alter this outlook.
00:24According to a research team, amyloid precursor, like protein 1, a surface protein on brain cells, could spread the material causing Parkinson's.
00:33A cancer drug targeting lymphocyte activation gene 3 was found to inhibit this process, suggesting an existing potential Parkinson's treatment.
00:43Xiaobo Mao, a neuroscientist from Johns Hopkins University, stated,
00:47Now that we know how APLP1 and LAG3 interact, drugs targeting this could significantly slow Parkinson's and other neurodegenerative diseases' progression.
00:59The majority of Parkinson's symptoms arise from a loss of dopamine-producing neurons in the substantia nigra.
01:06Misfolded alpha-synuclein forming Lewy bodies becomes insoluble and harmful, causing serious damage.
01:13Previous mouse trials found that LAG3 binds to alpha-synuclein proteins and spreads Parkinson's pathology.
01:22Another protein assists this process, leading researchers to target APLP1.
01:28For this study, researchers tested genetically modified rodents missing LAG3, APLP1, or both.
01:36Without both, 90% less alpha-synuclein was absorbed.
01:40The team used nivolumab, relatlimab, containing an antibody for LAG3.
01:46They discovered that it stopped the two proteins from interacting and almost completely stopped the clumps from forming in neurons.
01:53Dawson noted that this antibody was more effective due to APLP1's association with LAG3.
02:01Next, the team wants to test the antibody on Alzheimer's and Parkinson's mouse models.
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