00:00So this is a structure that was determined at the Center for Microscopy and Microanalysis here at UQ.
00:05What it represents is the fusion glycoprotein of nipovirus that is represented here in pink,
00:10green and blue. So it's a trimeric protein and in yellow what we have is the DS-90
00:16nanobody that can bind deep into a crevice that is present on this fusion glycoprotein.
00:21So the nanobody binds and it stays there and it neutralizes the virus by preventing the fusion
00:28glycoprotein from changing its conformation and shape and preventing the virus from fusing with
00:33the host cell. This is a structure of the fusion glycoprotein that was determined here at the
00:38Center for Microscopy and Microanalysis at UQ. So the fusion glycoprotein is represented here in blue,
00:44pink and green and the DS-90 nanobody is here in yellow and once the DS-90 body binds into this
00:50deep pocket within the spike fusion glycoprotein it can bind and then it can neutralize the virus.
00:58the
01:11so
01:13you
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