Algorithm Developed To Help Treat Behavioural Disorders

ETVBHARAT

A large number of trials for developing treatment for human behavioural disorders are being carried out on Zebrafish since it has shown parallels with humans.

Transcript

00:00How can we use the behavior?

00:05Because we need to make the behavior,

00:08we need to make the behavior,

00:11so we need to know the name of the diseases

00:14in which the behavior is important.

00:17If you have some big diseases,

00:21Alzheimer's disease, Parkinson's disease,

00:24Traumatic disorders,

00:27and fear,

00:29and the reward-seeking behavior,

00:34all these things

00:36give us the same level of the human being,

00:41and the same level of the disease.

00:44So if the person is struggling with the traumatic things,

00:48they are not productive,

00:50their lifestyle is reduced.

00:53Their life expectancy is reduced.

00:56So we need to change the behavior of the drug.

00:59As I said,

01:01to understand the behavior,

01:03to fix the behavior,

01:05to fix the behavior,

01:07if we have the drugs,

01:09then we need to measure the behavior

01:13so we need to use the zebra track,

01:15zebra fish,

01:16to use the behavior.

01:18We have made the name of the zebra track.

01:20We have made the name of the zebra track.

01:22We have made the name of the zebra track.

01:23Now we have made the star protocols,

01:26a very prestigious,

01:27from America,

01:28journal,

01:30and publisher,

01:32Cell Press.

01:34the journal,

01:35the star protocol,

01:36the cover page,

01:39we can see here.

01:41So the star protocols,

01:45the edition,

01:47the cover page,

01:49our article.

01:50The cover page,

01:51we have made the article.

01:52We have made the two big situations,

01:55we have made collaborative work,

01:57and we have made the start of 2016,

01:59and now we have published the Journal of Neuroscience Method,

02:04the Journal of Neuroscience Method,

02:07published the article.

02:09After that,

02:10we have made the step-by-step protocol,

02:14the star protocols,

02:16we have published the article.

02:18So,

02:19with Dr. Hari Singh and Vishwit,

02:21we have developed this technique,

02:25and we have worked on this technique,

02:27and we have worked on it.

02:29The final measurements of zebra fish

02:32was in IIT Hyderabad,

02:35Dr. Anamika Bhargo's lab,

02:37in the Biotechnology department.

02:41So,

02:42we have two people,

02:44one,

02:45one,

02:46one,

02:47one,

02:48one,

02:49one,

02:50one,

02:51one,

02:52one,

02:53one,

02:54one,

02:55one,

02:56one,

02:57one,

02:58one,

02:59one,

03:00one,

03:01well,

03:02one,

03:03one,

03:04one,

03:06one,

03:07one

03:08one,

03:09another

03:10administration,

03:12one,

03:13we would have done over it inievalops.

03:18So whether CCMP is a big lab or a big student or a state university or a financial and powerful lab,

03:30this software is applicable to everyone.

03:33Second, for human rights,

03:37the tools and techniques are not available to them.

03:53Now, when many people come to this field,

03:56the entry barrier is reduced.

03:58Now, there are many results in the market.

04:07The pre-clinical time period,

04:10which is about 5-8 years ago,

04:13can be reduced.

04:15As India and the world actually looks to reduce and restrict the use of animals in research,

04:22then we cannot, of course, altogether stop animal models in research.

04:27So we look for alternatives.

04:29And zebrafish emerges as a very, very important useful model organism.

04:35Its physiology is very close to humans.

04:37And it has already been proven a very good animal model, drug toxicity model, neurotoxicity model, etc.

04:45So we did actually with our collaborators at Dr. Harisingar University,

04:49we developed this method of measuring behavior.

04:53Behavior of zebrafish is a readout of any changes in the nervous system.

04:57Now, we did develop this method and we published this as a method.

05:02Now, the question is to be able to use this method,

05:05one needs a considerable expertise.

05:08And therefore, in this Stark Protocols journal,

05:11we had a step-by-step protocol where actually any,

05:15even an intern can take this protocol and execute it.

05:18So, basically this is our effort.

05:21This is our effort for a wider outreach of this method.

05:24This method.

05:34This method.

05:36This method.

05:38This method.

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