00:00Italian research is at a very high level in some of the most advanced sectors of world medicine,
00:10with the aim of making available as soon as possible innovative, precise and sustainable cures for a wide range of pathologies,
00:17often incurable, in the field of genetics, oncology, metabolic and cardiovascular, neurodegenerative, inflammatory and infectious.
00:25This is the essence of the National Research Center for the Development of Genetic Therapy and Pharmaceuticals with RNA Technology since 2022,
00:33year of its foundation, and that during the press conference on Genetic Therapy and RNA,
00:38the challenge of Italian research for a personalized and sustainable medicine,
00:42has illustrated the results of the first two years of studies funded by the PNRR,
00:47and now aims to attract new private investments to enhance the work of more than 1,500 Italian scientists and researchers.
00:55A great commitment to eradicate in Italy an emerging technology of the care of citizens,
01:05that is to fully exploit RNA, an extraordinary molecule that allows to act on any target within the cell.
01:15Genetic therapy, therefore the possibility of correcting defects or introducing new tools of care,
01:22so that new categories of drugs can be produced that are able to actually act on personalized medicine,
01:30that is, medicine that is able to identify the difference between patient and patient,
01:36and produce for each patient the most targeted drug,
01:40and therefore that will be more effective and with less side effects for the cure of diseases.
01:45The SPOC10, coordinated by the President of the Superior Council of Health, Franco Locatelli,
01:50focuses on the approaches of genetic therapy for the cure of hereditary diseases,
01:54the treatment of neoplasia or autoimmune diseases.
01:58Thanks to the funding received in the country,
02:01experiments have already been launched for the treatment of an acute leukemia variant,
02:10acute lymphoblastic leukemia of type T and neoplasia of the central nervous system,
02:17through a phase 1-2 protocol that puts our country at the forefront in the European context.
02:28Over the past few years, a zoo of different RNA molecules has been discovered,
02:33and now they are working to modify them and turn them into drugs.
02:37Drugs that can be both yin and yang,
02:41that is, they can be inhibitors of the genetic expression of a pharmacological target,
02:47or activators, and therefore we can inhibit the expression of some genes that are toxic,
02:54or increase others that are neuroprotective.
02:57Today we have understood, we have reasoned about how this is part of a wider spectrum plan,
03:06in such a way that Italy, on these issues, is at the forefront of the world,
03:12in such a way as to be able to take advantage of the excellent research that is taking place in our country
03:18and promote technological transformation in the construction of new drugs.
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