The United States will be favourites to beat Slovenia and believe they can handle the pressure at Ellis Park.
A 1-1 draw with England was a creditable opening result for Bob Bradley's team in Group C but will be forgotten if they slip up against a Slovenia side who beat Algeria in their opener.
"Going into a game as possible favourites would be different for us, especially in this World Cup, and that does pose a challenge... to know that you're under pressure to get three points, or get a good result," said defender Jay DeMerit.
Bradley is expected to stick with the same starting lineup as that which featured against England with goalkeeper Tim Howard having recovered from his bruised ribs.
Slovenia coach Matjaz Kek said his squad had analysed mistakes in a jittery first half against Algeria in an opening 1-0 win and knew dips in form could be costly versus stronger opponents.
Kek is likely to stick to his preferred 4-4-2 formation with Valter Birsa and Andraz Kirm on the flanks while captain Robert Koren and Aleksandar Radosavljevic should operate in the middle.
