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A two-year randomized trial at Keck Medicine of USC found that daily fish oil did not improve memory or thinking in older adults at higher risk of Alzheimer's. The study followed 365 adults aged 55 to 80 who rarely ate fish; 47 percent carried the APOE4 gene variant. Participants took 2,000 milligrams of DHA daily, and spinal-fluid DHA rose an average of 17 percent after six months. Scores did not beat placebo, and the study did not prevent brain shrinkage. eBioMedicine published the single-trial findings.
Disclosure: This video contains stock footage and content created or enhanced using AI-assisted tools.

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00:00A two-year study found that fish oil did not improve memory in older adults.
00:04Researchers at Keck Medicine of USC tested 365 adults aged 55 to 80.
00:10All rarely ate fish and were at higher risk for Alzheimer's disease.
00:15About 47% carried the APOE4 gene variant.
00:18Participants took 2,000 milligrams of DHA, an omega-3 fatty acid, every day.
00:24After six months, DHA in spinal fluid had risen by an average of 17%.
00:29So the supplement did reach the brain.
00:31But memory and thinking scores were no better than with a placebo.
00:35It also did not prevent shrinkage in the hippocampus, a key memory area.
00:40The lead researcher said the results do not support fish oil supplements as a preventive measure.
00:45Researchers suggest omega-3s may work better within a broader diet, such as a Mediterranean-style pattern.
00:52But that idea was not tested in this trial.
00:54Disclosure.
00:55This video contains stock footage and content created or enhanced using AI-assisted tools.

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