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  • 1 week ago
Researchers at the University of Sydney analyzed 11,380 people with depression and identified a possible circadian subtype affecting about one in four. People with this pattern often have a body clock that feels permanently jet-lagged, an evening chronotype, a late sleep midpoint and morning tiredness. They were less likely to benefit from common antidepressants, and the team suggests light therapy and melatonin may deserve earlier attention for this group. The finding comes from an association study and needs to be confirmed.

Disclosure: This video contains stock footage and content created or enhanced using AI-assisted tools.

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00:00Researchers at the University of Sydney have proposed a new circadian subtype of depression.
00:05They analyzed 11 380 participants in the Australian Genetics of Depression study.
00:11About one in four fit the subtype, which is defined by six criteria.
00:15These include an evening chronotype, a late sleep midpoint, social jet lag, and morning tiredness.
00:21Senior researcher Ian Hickey describes it as feeling jet lagged all the time.
00:26People with this subtype had earlier onset of depression and more severe features.
00:31They were also more likely to gain weight during episodes.
00:34They were less likely to benefit from common antidepressants and reported more side effects.
00:39The team suggests body clock treatments may be more relevant for this group.
00:43Examples are light therapy and melatonin.
00:46The findings were published in the British Journal of Psychiatry.
00:49Disclosure. This video contains stock footage and content created or enhanced using AI-assisted tools.

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