00:00Nearly a quarter of people with depression, in a large Australian study, shared a body clock pattern.
00:05That could help explain why common antidepressants work less well for some patients.
00:10Researchers at the University of Sydney studied more than 10,000 people with depression.
00:15They identified 2604, with a subtype they call circadian depression.
00:20It is tied to the body's 24-hour internal clock.
00:23Signs include a seasonal pattern, sleeping longer when low and waking very tired.
00:28People with this subtype also tend to be night owls.
00:31Their depression often started earlier in life, with more severe symptoms.
00:36This subtype appears more resistant to SSRI antidepressants.
00:40It may respond better to melatonin-based treatments and light therapy.
00:44The study looked at people with severe, recurring, or long-lasting depression.
00:48For nearly a quarter of them, the body clock may be part of the story.
00:52Disclosure. This video contains stock footage and content created or enhanced using AI-assisted tools.
