00:00Chronic cigarette smoke exposure changes lung stem cells in ways that make them vulnerable to specific cancer mutations.
00:06Researchers found these altered cells respond differently to mutations in crase and TP53 genes,
00:13which drive distinct lung cancer types, using lung organoids exposed to smoke condensate for six months.
00:19They observed epigenetic changes that create precancerous cell states.
00:23Smoke-exposed cells with crass mutations developed adenocarcinomas from bronchioalveolar stem cells,
00:30while TP53 loss led to squamous cell carcinomas from basal stem cells.
00:35Michelle Vaz, senior author, says the genetic event alone is not sufficient,
00:40and smoke exposure primes cells for cancer.
00:43These findings reveal how smoke reshapes lung cells to favor certain cancers and could guide early detection and treatment.
00:50Disclosure. This video contains stock footage and content created or enhanced using AI-assisted tools.
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