00:03hi guys I'm Emily Wong and just like I said in my previous video I'm a pharmacy student who just
00:11wants to share with you what I've learned about different types of medications my information
00:17will generally be from word of mouth so don't apply anything I say to the drugs you want to try
00:23or how you want to structure your way of living this video is purely for entertainment please
00:29read the disclaimer in the description okay so I would like to start with drugs that are as of the
00:38time of this video posting rumored to increase a person's lifespan and possibly turn back the
00:47aging clock at least a little bit the drug is called senolytic senolytic therapy represents a
00:55groundbreaking approach in the quest to extend healthy human lifespan by specifically targeting
01:02and eliminating senescent cells cells that have stopped dividing but refuse to die this therapy
01:07aims to rejuvenate tissues and restore youthful function cellular rejuvenation at the heart of
01:14senolytic therapy holds the promise of addressing the root causes of aging rather than just its symptoms
01:20this innovative field is seen as a paradigm shift in longevity science because it moves beyond
01:27traditional treatments offering the potential to fundamentally alter how we age and experience
01:33age-related diseases senolytic therapy represents a groundbreaking approach in the quest to extend
01:39healthy human lifespan by specifically targeting and eliminating senescent cells cells that have stopped
01:46dividing but refuse to die this therapy aims to rejuvenate tissues and restore youthful function cellular
01:53rejuvenation at the heart of senolytic therapy holds the promise of addressing the root causes of aging rather
02:00than just its symptoms this innovative field is seen as a paradigm shift in longevity science because
02:07it moves beyond traditional treatments offering the potential to fundamentally alter how we age and
02:13experience and experience age-related diseases senolytic therapy represents a groundbreaking approach in the
02:19quest to extend healthy human lifespan by specifically targeting and eliminating senescent cells cells that
02:27have stopped dividing but refuse to die this therapy aims to rejuvenate tissues and restore youthful function
02:33cellular rejuvenation at the heart of senolytic therapy holds the promise of addressing the root causes of aging rather than
02:42just its symptoms
02:42this innovative field is seen as a paradigm shift in longevity science because it moves beyond
02:49traditional treatments offering the potential to fundamentally alter how we age and experience age-related
02:56diseases healthy cells follow a well-regulated life cycle that ensures the proper functioning of tissues and organs
03:04each cell carries out specific roles such as transporting nutrients generating energy or supporting immune responses
03:15cells divide through a process called mitosis allowing the body to grow repair damage and replace old or worn out
03:23cells
03:24equally important is apoptosis or programmed cell death which removes cells that are no longer needed or are functioning abnormally
03:33abnormally this balance between cell division and cell death is essential for maintaining
03:39overall tissue health and preventing disease cellular senescence is a state in which cells lose their ability to divide
03:48often as a result of damage or stress instead of dying off as they should these cells enter a kind
03:58of suspended animation
04:00scientists sometimes refer to them as zombie cells because although they are no longer functioning normally they persist within tissues
04:11over time these zombie cells can accumulate potentially disrupting healthy cellular processes and contributing to age-related diseases
04:20senescent cells though no longer dividing can have detrimental effects on the body they release a mix of inflammatory molecules
04:29known as
04:29the senescence associated secretory phenotype or SASP these factors contribute to chronic
04:36inflammation and can degrade surrounding tissue impairing normal function additionally the presence of senescent cells can
04:45influence neighboring healthy cells spreading dysfunction and accelerating tissue aging over time the accumulation of
04:53of these cells is linked to various age-related diseases and a decline in overall
05:00tissue health cellular senescence is an evolutionary adaptation that serves as a crucial defense mechanism against cancer
05:09by halting the division of damaged or stressed cells senescence prevents the uncontrolled cell growth that can lead to tumor
05:18formation
05:19addition additionally this process plays a beneficial role in acute injury repair
05:25as senescent cells can promote tissue regeneration and healing
05:30however as organisms age the accumulation of senescent cells can become detrimental
05:36contributing to chronic inflammation and tissue dysfunction
05:41this dual nature highlights the complex balance between the protective and harmful effects of cellular senescence throughout life
05:49senolytics are a class of therapies designed to specifically target and remove senescent cells from the body
05:56these cells which have stopped dividing but do not die can accumulate over time and contribute to aging and various
06:06diseases
06:06senolytic treatments which include both natural compounds and synthetic drugs work by identifying and eliminating these harmful cells
06:15while leaving healthy cells unharmed
06:18this selective approach aims to improve tissue function and promote overall health
06:23senolytics are a class of drugs designed to target and eliminate senescent cells often referred to as zombie cells
06:30these cells persist in tissues by activating specific survival pathways known as SCAPS or senescent cell anti-apototic pathways
06:42senolytics work by disrupting these pathways effectively disabling the cellular mechanisms that prevent programmed cell death or apoptosis
06:51once these protective barriers are removed the senescent cells become vulnerable and are efficiently cleared by the body's natural processes
07:00this targeted approach helps to reduce the accumulation of dysfunctional cells which can contribute to aging and various age-related
07:10diseases
07:11recent research including studies conducted by the Mayo Clinic has revealed promising results for senolytic therapy
07:20scientists have found that this treatment can restore levels of protective proteins such as clotho which play a crucial role
07:27in maintaining cellular health
07:29by increasing clotho senolytic therapy helps tissues become more resilient to stress and damage
07:37these findings suggest that targeting senescent cells may offer new ways to support healthy aging and improve overall tissue function
07:47senolytic therapy is being explored for its potential to target and eliminate senescent cells which accumulate with age and contribute
07:56to various age-related diseases
07:58natural supplements such as fiscitin and quercetin have shown promise in preclinical studies for their senolytic properties
08:06in addition to these natural compounds pharmaceutical interventions are undergoing clinical trials to assess their safety and effectiveness in humans
08:16these therapies aim to improve health span by reducing the burden of senescent cells in tissues
08:22as research progresses senolytic treatments may become a valuable tool in managing aging and age-associated conditions
08:32senolytic therapy targets and removes senescent cells which are known to contribute to chronic inflammation in the body
08:40by clearing these cells the therapy helps reduce inflammation a key factor in many age-related diseases
08:48research suggests that senolytics can delay the onset of conditions such as cardiovascular disease
08:56diabetes and neurodegenerative disorders as a result individuals may experience an extended health span
09:04maintaining vitality and function for a longer period these promising benefits highlight the potential of senolytic therapy in promoting healthier
09:14aging
09:15for young adults understanding the significance of preventative maintenance at the cellular level is crucial for long-term health
09:26by adopting healthy habits early individuals can help protect their cells from premature aging and damage
09:33the emerging field of senolytic therapies offers promising possibilities aiming to target and remove aging cells to support tissue regeneration
09:42as research advances these therapies may play a vital role in the future of regenerative medicine
09:48potentially extending healthy lifespan and improving quality of life
09:54thank you for watching and listening closely to me stammer throughout this presentation
09:58marie says i'll improve in time she's more of a natural at this than me
10:03this is the start of a series of medical treatments that have been set to extend years to your life
10:10so i'll have a second part to this soon
10:13if you like the music it's by stories in my head
10:16leave a request in the comment section if you want to ask marie where you can purchase these tracks if
10:22you want them
10:23i'm sure that she'll quickly reply with that information
10:26well i hope that you've enjoyed this food for thought
10:29it was my pleasure putting this together
10:31i'll see you again soon take care
10:34you
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