00:00Dental regeneration is not just a dream, it is the new frontier of science in dentistry.
00:05And today we're going to see how a new technique is being developed to, let's say,
00:10Grow organic seeds to grow new teeth in your mouth.
00:14This is the fourth video he has dedicated to the topic of dental regeneration research.
00:19who are seeking to develop techniques that can grow a third generation of teeth in humans.
00:25When a person loses their teeth, dentistry today offers a range of proven and detectable solutions.
00:31such as removable dentures, preppy dentures, dental implants,
00:35These are treatments that dentists use today to restore your smile and your ability to chew.
00:41But science seeks to go one step further, to offer you something better, another alternative.
00:46Imagine if in the future modern dentistry allows us to add, to add tissue to your bone,
00:53to your jaw, to your maxilla, so that a new tooth can grow in your mouth.
00:57So, instead of metal or ceramic, you would have a new living tissue,
01:02a new dental organ that communicates with its environment, with the bone.
01:06The research on which I base this video,
01:08He seeks to get cells to organize themselves in the laboratory,
01:12form tissue and then bring them to your mouth.
01:14This is about tooth germination, which is still in the study phase.
01:17I am dentist Luis Marcano, and to understand the core of this video
01:21And regarding the research I'm talking about, first we're going to talk about organoids.
01:24But what are they?
01:25Organoids, simply put, are miniature and simplified versions of organs.
01:31They are created in a laboratory and mimic the function and structure of a real organ.
01:36Or to put it another way, they are a miniature three-dimensional version of those organs.
01:41And in the case of this research on dental regeneration,
01:44These are organisms that already have biological instructions to develop.
01:48Now we come to an important question.
01:50How does he intend to achieve this, and what would its clinical application be?
01:53One difference is that Dr. Volponi's research aims to use a hydrogel
01:58to achieve dental regeneration.
02:00And this hydrogel is like a gelatin that is derived from collagen.
02:04In other words, it would be compatible or, very safe for you and your body.
02:09This hydrogel would be used in such a way to cultivate those cells, then bring them to your mouth
02:15And after being inserted into the bone, this hydrogel disappears, being reabsorbed by the bone
02:20and be replaced by tissue, by bone, by the periodontal ligament.
02:24In other words, its function would be temporary, but essential for the development of a new good.
02:28The science they apply to these hydrogels is something they call click chemistry or click hydrogel.
02:34What they are trying to do is give it a specific anesthetic to allow the stem cells to communicate with each other.
02:41The function of this new hydrogel technology would be to act as a vehicle,
02:46to facilitate cellular life, the development of that organoid and then for that hydrogel to disappear.
02:52However, I must clarify that this technique differs from the technique used by two researchers.
02:57I'll clarify this for you, as I mentioned in the second video about dental regeneration, because I also mention it in this video.
03:02I talked about stem cells.
03:03In that other investigation they seek to guide tooth growth.
03:08If you haven't seen the video, I invite you to watch it when you finish this one.
03:10But in this research I'm talking about organoids that have the biological instruction to become a tooth.
03:17But like all research, like the previous ones I've mentioned and like the future ones I'm going to talk about
03:21also,
03:22It has its limitations and challenges, for example, controlling the shape and size of the tooth.
03:28But let's talk about one of the advantages of this technique, which is integration.
03:32Unlike a dental implant, which is an inert material, the new tooth is a biological tissue.
03:37with communication with its environment, with the perianal tissue, with the bone.
03:42And this means that the new tooth would promote the growth of your jawbone in that area.
03:48stay active.
03:49And this is vital to prevent bone loss that people suffer after they lose a wind.
03:55Some at higher speeds, others at lower speeds.
03:58It's about using biotechnology to go beyond the levels that nature has set in the
04:03humans.
04:04This technique using organoids created in the guard seeks to create a natural connection.
04:09which is the connection that the tooth has with your bone.
04:12However, I must clarify that I have an ongoing research project,
04:14It's not something we have available in dental practice today.
04:17Besides, one of the additional challenges of this research is to make this technique equally effective.
04:25at all ages.
04:26Because the cellular response is not the same in younger people as in older people.
04:30And regarding the price, we still need to achieve the goal of re-grinding teeth with this technique to discover what it is.
04:36its market price.
04:37Because this is one of several techniques.
04:39For example, in another video I talked to you about the drug developed in Japan.
04:42In another video I talked about an LK1 gene that can also be used to re-groove teeth.
04:47I've included them all in a playlist that I invite you to check out.
04:51Until the next video.
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