00:00And if we could erase tooth loss by taking just one new medication,
00:05Dental regeneration has gone from being an impossible dream to a drug that is currently being tested on humans.
00:10We are just a few steps away from dental regeneration becoming a practical treatment in the
00:16dentistry,
00:17which would save you from dental implant treatment.
00:20Imagine that in your upper and lower jaws there is a factory for making new teeth,
00:24But a factory that has been around for years, yet the machinery is still there.
00:27Dr. Katsu Takahakin's team suggests that we all have, let's say, some seeds for a third set of teeth.
00:34But the possibility is that the third set of teeth will die before it is born, so to speak.
00:38But why does this happen?
00:40Here we arrive at the culprit, which is the USAC-1 protein,
00:44protein that acts as a kind of security guard preventing the factory from reopening to make new
00:50teeth in your mouth.
00:51In other words, it ensures that the factory remains closed and inoperative.
00:54The incredible scientific advance is not in creating a new synthetic tooth,
00:59We already do that to some extent in dentistry,
01:01but it led to the creation of a drug, a medicine that neutralizes this protein
01:06and opens the doors for your body to generate new natural teeth.
01:10What this research team in Japan is seeking is for this drug to activate,
01:15flip a switch that sets this machinery in motion in your body
01:19And new teeth can be produced when you need them, of course.
01:22And this is not science fiction, but a step that has brought us closer to a new kind of
01:26dental treatment,
01:28thanks to a new form of molecular therapy.
01:30The goal with this new drug that they are researching and developing in Japan
01:34It's about getting your own body to participate in the treatment, making it generate and regenerate new teeth.
01:41I'm dentist Lul Marcano, and today we're analyzing Dr. Katsu Takahashi's research.
01:45who seeks to transition to dental implants after retirement.
01:48But who exactly is Dr. Takahashi?
01:51Dr. Katsu Takahashi is the head of oral surgery at the Kitana Hospital Medical Institute in Osaka, Japan.
01:58And he has spent decades researching, searching for the answer to the question.
02:02Why do some animals regenerate new teeth and humans don't?
02:06Why are humans limited to two sets of teeth?
02:09In one of his investigations, which I'm showing on the screen right now,
02:12Dr. Sakakatsu Takahashi says that the key lies in molecular control
02:16The drug that he and his team have been developing is, in a way, a monoclonal antibody.
02:22In other words, it's like a master key that only fits that Usak-1 protein.
02:27and that manages to inhibit the function of this protein and make the body, our body, generate new teeth.
02:34In other words, by blocking that protein, what they are trying to do with that parma is send a signal to the
02:39stem cells,
02:39your stem cells to generate new teeth.
02:42It is a process of regenerating natural teeth but driven by modern parapharmacology.
02:47In fact, they have grown new teeth in rats and ferrets with a single dose of this drug.
02:53And these teeth have had perfect anatomy; they are not a lump of calcium or dental enamel.
02:58but rather they are functional teeth with enamel, dentin, and pulp.
03:02But the investigation has not stopped there.
03:04In fact, Dr. Takahashi's team first released human trials on patients suffering from dental malformations.
03:09So what does all this tell us?
03:10So far, this drug they have been developing has proven to be safe and effective.
03:16To fulfill the objective of making new teeth.
03:18Let me clarify, I'm not saying that this new medication will be available at your nearest pharmacy tomorrow.
03:23No.
03:24It is also not entirely clear whether it will be an over-the-counter drug or for exclusive use in the
03:28dental consultation.
03:29But what is being said is that dentistry has achieved the regeneration of new teeth.
03:35But, and this is a question that interests you greatly, when might this new drug be available?
03:39This research by Dr. Takahashi and his team has been conducted under the auspices of the company Toregen Bioparma, a
03:46pharmaceutical.
03:47Chésimas do not guarantee it, but they predict that the drug could be available by 2030.
03:53This type of research marks a turning point in the history of science.
03:56Because dental regeneration would lead to the production of new teeth with pulp, with periodontal ligament, things with which
04:03Dental implants do not count.
04:05And these are elements that give your mind sensitivity, a natural sensitivity, and that give it communication with
04:11the human body.
04:12And although by this time, for the implementation of this dental pharmacogen, a bridge is already being built that
04:18It will shift dentistry from a dentistry of replacement with prostheses to a dentistry of dental regeneration and rebirth.
04:25And regarding dental regeneration, Dr. Takahashi's research is one of several bridges to come.
04:31building because there are other lines of research regarding growing dead teeth.
04:35Until the next video.
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