00:00A new research may change how cancer patients approach their diets.
00:04Now, sucralose is a popular artificial sweetener.
00:07Many people use it as a sugar substitute to cut calories or manage blood sugar.
00:12But scientists from the University of Pittsburgh and UPMC Hillman Cancer Center have found
00:17that sucralose may not be the best choice for some cancer patients.
00:22Their study focused on patients with melanoma and non-small cell lung cancer
00:26undergoing a type of treatment called immunotherapy.
00:28Now, immunotherapy helps the body's immune system attack cancer cells.
00:33It's a breakthrough in cancer care.
00:35However, the researchers have found that patients who consumed high levels of sucralose
00:40responded worse to immunotherapy.
00:43They also had lower survival rates.
00:45This finding is concerning because many cancer patients rely on diet sodas or sweeteners during treatment.
00:52So, what causes this negative effect?
00:54Well, the answer lies in the gut.
00:56Sucralose changes the makeup of gut bacteria in mice.
01:00Some bacteria that grow with sucralose break down an important amino acid called arginine.
01:05Arginine is essential for immune cells called T-cells to work properly.
01:10Now, T-cells are key players in fighting cancer during immunotherapy.
01:15When sucralose reduces arginine, T-cells cannot do their job effectively.
01:19This means that immunotherapy is less successful.
01:22The team ran experiments with mice models of melanoma and adenocarcinoma.
01:28They saw that adding sucralose to the diet led to larger tumors and worse survival.
01:33But here comes the hopeful part.
01:35When mice given sucralose also received arginine and citrulline, a related nutrient converted into arginine in the body,
01:42the immune response improved.
01:44Immunotherapy worked better, tumor growth slowed, and survival rate increased.
01:50This suggests that supplementing with arginine or citrulline could counteract the harmful effects of sucralose on immunotherapy.
01:58Now, the researchers then looked at data from 132 cancer patients receiving immunotherapy.
02:04What they did is they reviewed patients' diet histories, including artificial sweetener intake.
02:09They found that the same pattern as their high sucralose consumption was linked to poorer immunotherapy outcomes.
02:17This study highlights a new area of concern for cancer treatment.
02:22But at the same time, it also offers a potential solution through simple nutrient supplements.
02:28Lead researcher of the study, Abhi, says that it's not realistic to ask cancer patients to completely change their diets during treatment.
02:35But what can be done is boost arginine levels with supplements might be an easier, effective way to support immunotherapy.
02:45Now, the team plans to launch clinical trials testing citrulline supplements in cancer patients.
02:51They want to see if it can improve gut bacteria and immune responses.
02:56They also plan to study other sugar substitutes like stevia.
03:00The goal is basically to understand how these sweeteners affect cancer treatment.
03:06This research reminds us that diet plays a very important role during medical treatments.
03:13What we consume can influence therapy success.
03:17For cancer patients and doctors alike, understanding these connections is vital.
03:23Nutritional choices and supplements might one day improve treatment results.
03:27Sucralose may harm cancer immunotherapy by disrupting gut bacteria and reducing arginine.
03:33But arginine or citrulline supplements show promise in reversing these effects.
03:38This discovery could lead to new approaches that help cancer patients get the most from their treatments.
03:45Stay with us for more updates on groundbreaking research.
03:57Stay with us for more undone for medical advice.
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