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00:00Is this deal a surprise for Sanofi?
00:03Very much so, because we're seeing this situation, obviously, where vaccines globally,
00:08we're seeing sort of a hit to vaccine sales. Sanofi itself has said at the last quarter
00:14that its vaccine sales were down. In the US, we have a health secretary, Robert F. Kennedy,
00:20who is almost systematically undermining some of the tenants of vaccines, really.
00:26But what we have seen is that's mainly targeting childhood vaccinations, and this deal is mainly
00:32focused on adult immunizations. So I'm assuming that Sanofi is hoping that adult immunizations
00:38are protected from those changes that we're seeing in the US. And obviously, this deal might take
00:45several years to sort of show true value for the company. So we might see changes in the rules
00:52around vaccines in the coming years in the US. Okay. So actually, that's the vaccine story
00:58around Sanofi. Today, Sanofi has also said that the US FDA rejected its drug for multiple sclerosis.
01:05What does that setback mean for the French drugmaker?
01:08So this is a significant blow. We'd already, in a way, expected difficulties with the submission.
01:16The FDA had already delayed the decision date, and we were expecting this to potentially come
01:23next year. It's a surprise that this has come so quickly. And it's also a significant blow,
01:29potentially, to patients with a specific type of MS, which have few options. But for Sanofi,
01:35which is really trying to replace its leading drug, Dupixent, and that's coming, generics are coming
01:41in the next couple of years for that drug. And this MS drug was supposed to sort of help it
01:47on its way to sort of replace those revenues. So this rejection in the US is going to be significant
01:53for it. Sanofi seems to hope that there's still a way forward, and it's still discussing with us
01:59with the FDA. But obviously, it is a significant blow. This was the potential for 1.7 billion US dollars
02:06and peak annual revenue, which would, you know, those sales will only potentially come from the
02:12rest of the world now.
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