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00:00I think cancer plays the role of a bogeyman in society. It has evolved with
00:09us, it is part of us, and it kills without prejudice. We can't continue to
00:17catch cancer at the last throes of its existence when it is killing people.
00:24Wouldn't it be amazing to actually go one step further and stop cancer from
00:31starting at all? Research is where hope starts. It's optimism and it's a belief
00:40that we can know what is currently unknowable, and that's the challenge.
00:47Ultimately, it could change the world. For generations, a cancer diagnosis left
00:54almost no hope. It's a terrifying disease that has stalked us for millennia. I
01:01didn't expect I had cancer because all the tests were coming back negative. I
01:05don't think my body can take anymore. Science has fought hard against it, and now
01:11the tide is finally turning. One of our key goals is to transform this idea of
01:17cancer as a death sentence. A group of trailblazing scientists are making new
01:23breakthroughs. We now need to take those discoveries and make them work for
01:29patients. This is the world's first lung cancer prevention vaccine. Discovering
01:35cures and finding ways to stop cancer before it even starts. The tumour seems to
01:42be shrinking. Shocked. No, I've got wildest dreams. I would have expected that. Creating a
01:46future where cancer doesn't win. We're getting very close to defeating cancer once
01:53and for all. What's not curable today could be curable tomorrow.
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02:25Trevor yeah good morning on time then but they have taken lots you can yes I if you couldn't
02:35find a vein we'll see how we get on today I think we'll go for our favorite thing yeah
02:41right Saturday she got in there fine did you know yes 68 year old Trevor is at the Churchill
02:49Hospital in Oxford being treated for skin cancer I have melanoma so I had a water my head my wife
03:04would be nagging me for at least a year to go and see and I didn't so I should have because I might
03:12not have been in the stage where I am now but you know this is life
03:19first time as well keep up that track record day I had that cut out in Southampton hospital and then
03:35they found I had secondaries in my liver and that way could have a year to live
03:42so I'll take your place down to the lab hopefully we'll get resolved within an hour hour and a half
03:52yeah right here and then hopefully we'll get there and get treatments in it lovely thank you very much
04:01hi dad yeah come in I'm all right do you want a hot drink at all no I'll just have a water thank
04:17you he's a typical Navy man very firm strict didn't want to go and get any help but eventually did oh
04:26the clouds come in again I think coming from that background becoming a patient is quite vulnerable
04:33how is your start at healing now well it's better than what it was isn't it yeah a lot better when I
04:41went in for the surgery when the procedure come in and he sort of goes yeah we've got we've got to
04:47cut something about that out ultimately we all know that life starts being born and it ends with
04:59death and we've all got to go through them all but almost felt too early I felt angry I felt upset I
05:09didn't want to let him know that I was worried and it's almost like you go into protective mode of your
05:15whole family our siblings looking out for each other the grandchildren what they were going to
05:20miss out on what we were going to miss out on them hard conversations moving forward that we were
05:25going to have to have I suppose life's up to go on hold a little bit for you dad well if I'd gone
05:31when Janice told me in the first place I might not I've got this far so yes I can to blame myself
05:37but I didn't listen Janice and I should have probably gone a year earlier but yeah maybe it's a
05:43man thing is that yeah I was gonna say it's typical sometimes it's a journey in itself every little clip
05:54of the way of the journey is a rollercoaster of emotions in Oxford Trevor is under the care of
06:09professor Sarah Blackton good morning hi Trevor how are you getting on yeah good thank you very much I
06:16thought it'd be quite useful to show you the images of your of your cancer cells okay I've got them up
06:24here on the monitor do you want to have a look as you know your cancer started in your head and one of
06:31the things that they reported at the beginning was that they found about four spots on your liver
06:35cancer is basically our own cells going rogue changes to your cells can cause uncontrolled cell
06:47division the mass of these rapidly growing cells competes with our normal cells and becomes a tumor
06:56the tumor learns to evade our immune system and over time the tumor then blocks blood vessels it blocks
07:05airways spreads to other organs in our body and damages them as well and if untreated it can drain
07:13our body's resources until ultimately we die of the disease with previous treatments having failed Trevor's
07:24only hope was to join Sarah's immunotherapy trial our bodies have quite a lot of clever defenses against
07:32cancer our immune systems are constantly watching so a lot of the work we're doing at the moment is to
07:39try and really understand it so that it's better able to recognize cancer the therapy trains Trevor's
07:46immune system to identify and attack cancer cells so here is the liver you can see that these black dots look
07:54abnormal it's a treatment that doesn't work for everybody Trevor's progress is gauged by routine scans of his tumors
08:03the ones that are quite regular like that one to me that looks like a cyst so that's nothing to
08:11worry about but the ones with the sort of irregular edges like that one look more like the cancer deposits
08:18and that's exactly what was reported they were growing before you started the study they were you
08:23know at least two and a half centimeters and now they're kind of just static and the question is are
08:28there any active tumor cells in those deposits so what we would like to do now is arrange a PET scan and use
08:36that scan to measure the amount of activity going on in those liver deposits to see whether there's any
08:42active cancer there I'm sensible enough to think that the chances of it going away completely I think
08:50a swim but you know you live in hope well I mean you know for the best result that's right I mean with
08:56the immunotherapy studies they've done so far about half of the people respond well and 20 years later
09:03many of them still haven't got disease back yeah so it could be that you will have a long remission and
09:09and one day one of us will might say the word cure remission would just be nice yes yeah yes
09:17go back to reality yeah but well we'll see we'll see who knows
09:24before immunotherapy we didn't really understand the full power that the immune system has against cancer
09:38but this has completely transformed it for us because it's enabled us now to realize that we
09:43might be able to harness that very very powerful immune response at a cancer before it starts rather
09:49than waiting until it has started by 2040 the number of new cancer cases each year in the UK is expected to
10:04rise to over half a million hi hello nice to see you Peter how are you I'm doing okay thank you you're
10:11doing all right considering on the ward where Sarah works 150 people regularly come to take part in the
10:19clinical trials I'm a clinician scientist which means that I'm half a practicing doctor an oncologist who
10:27looks after cancer patients and the other half I'm a scientist so I do research on cancer oncology
10:36you're dealing with the day-to-day reality of cancer and all its frustrations when you know
10:43what cancer does when you know how long it takes sometimes decades to develop in our bodies when you
10:50know those various steps it goes through before it becomes cancer and that there is such a long
10:57window that we are currently not intervening it feels to me morally wrong not to go and explore that
11:05further and actually do something to stop it much earlier I would feel very dissatisfied if I wasn't doing
11:15this right now because I really feel like I want to make some small amount of difference I have a big
11:24idea which is building on our knowledge from immunotherapy to really design a series of vaccines
11:33against specific cancers but then to pull them all into a single vaccine that you would give to
11:40everyone to protect them from cancer I will demonstrate with fruit okay imagine that this is a normal
11:48cell okay and normal cells communicate with our immune system via a flag system and basically these
11:56are just a string of proteins or amino acids and the immune cell comes past sees it and it says
12:02everything's fine and it carries on when the normal cell is unwell or anything abnormal happens in the
12:09cell it then changes the signal and signals something abnormal and the immune cells come
12:14past and they just basically recognize okay this isn't right it binds to the cell and it destroys that
12:20abnormal cell and this is a really important way that our cells remain healthy in our bodies what we know
12:26about cancer cells is that they also have very abnormal signals but unfortunately we're not very
12:34good at eradicating cancers from our bodies effectively what happens is the cancer cell evades the immune
12:40system with a kind of cloak of invisibility so that means that although they are flagging some abnormal
12:46proteins on the cell surface the immune cells can't recognize this and this enables the the cell to grow
12:53and grow and grow and become a really nasty established invasive cancer somewhere in the trajectory between
13:00a normal cell becoming a cancerous cell it goes through a precancerous stage and we know now that
13:06that takes about 10 years I liken it to a sort of cocoon and moth you know the cocoon stage is the
13:15precancer stage and it's a stage that can take about a decade before the moth or the cancer actually occurs
13:23so it's perfectly possible that you or I have a cancer already developing in our bodies that will not be
13:32diagnosed probably for another decade and during that stage again the cell is signaling to the immune system
13:40that it's not well that it's not right but it hasn't acquired this cloak of invisibility and most times our immune
13:49cells are very good at eradicating recognizing this abnormal and eradicating these pre-cancers
13:55and this is probably what happens in our bodies all the time so we're probably constantly eradicating
13:59pre-cancer but some of these cells are breaking through and they are escaping the immune system
14:07and that's probably how cancer starts in the first place so what we're doing with the vaccines is we're
14:13basically teaching the immune system to better recognize those early changes here to prevent this
14:20from then becoming a cancer
14:25we have this sort of ticking time bomb within us
14:29i feel a real sense of urgency because i think that we have a once in a generation opportunity to bring
14:35together the technologies and the research that's being conducted this is an opportunity that can't wait
14:42the opportunity is now
14:51you're having your transfusion today how are you feeling you must be exhausted i am
15:21very exhausted yeah to bed in the afternoons for sleep what we call cancer is at the end of a
15:28very long disease process that's taken place in our bodies and at this point in time that process is
15:34too often being allowed to happen without any intervention whatsoever
15:44sarah leads a research group at the university of oxford to develop the vaccine
15:49in the last 50 years research has helped double cancer survival but it's not all good news
15:56we know that the incidence of cancer is growing year on year cancer is on the rise and we need to do
16:02something about it soon
16:06our destination is ultimately to protect everyone against cancer
16:10and lung cancer is the most common cause of cancer death in the uk there are almost 50 000 cases of
16:25lung cancer diagnosed every year
16:29with the lung cancer vaccine we have taken and modified a virus and loaded it with genetic instructions
16:36and these instructions are teaching our immune cells to recognize early changes that happen in the lungs
16:44as they transition towards cancer
16:47so what we're doing is we are teaching your immune cells
16:51we're priming them to recognize and destroy pre-cancerous cells as soon as they start to develop
16:58and these cells are then able to pass that knowledge around to more and more immune cells
17:06which can then patrol the lung and other tissues for any cells that are starting to transition towards cancer
17:13the vaccine
17:16and the vaccine is a post-doctoral researcher leading the pre-clinical lab testing of the vaccine
17:24my job is to test that we can actually train immune system to see and attack cancer cells
17:32so we need to show that the vaccine can do a job so we can take it into a clinical trial
17:40when i first came up with this idea i felt too embarrassed to say it in public because it just
17:46seemed ludicrously optimistic but actually we're starting to think maybe it isn't such a mad idea
17:54i often walk to get you know a drink or food and then you see patients who have exhausted all of
18:02their treatment options of course you want to do something that is going to help them have better
18:08quality of life so from that point of view it keeps you going but there is also that stress how fast
18:13can i get there zinaida will present the results to sarah when the tests are complete
18:20it's really important to show that the vaccine works in cells before we take it into people if it
18:30can't then we've designed it wrong just coming
18:43hello hello hi hi hi hi good i wanted to be a doctor since i was about six so i want to see
18:54this trunk oh yes right i mean i did have a phase of wanting to be a ballet dancer
19:00okay oh my god it's massive i think i was a little bit too physically lazy for that
19:06i got the lead line i remember at one point i had an insect hospital and i had little beds for
19:11injured insects wow it's like a treasure trove yes i don't know i suppose i probably wanted to heal
19:19them hey look at this dad's medal right do you want to keep that mom
19:29i think i was quite serious actually as a kid we were an army family and we moved around a lot
19:34and we would be expected to kind of behave and turn up at things and you know curry lunches and
19:41parades and all that sort of stuff that army brats have to do what is this that's a land mine obviously
19:48it's not live no my father cleared minefields out in war-torn places around the world oh there's dad
19:59i think his frustration was its impact on civilians you know people who had no intention of getting
20:06drawn into a war and 10 years later might be walking a field and then suddenly a land mine going off
20:18do you remember i was doing my pathology exam and i was totally stressed and daddy was working for
20:22the un at that point and he was about to go and clear some mines i rang him and said i'm really
20:27terrified i've got this exam i've decided i'm not going to sit it i'm going to back out because i can't
20:31do it i'm too stressed and dad said sarah one of us is going to do an exam tomorrow and one of us is
20:38going to a minefield which one would you prefer to be he genuinely wanted the world to be a better place
20:50he was a problem solver
20:51and i do think about him quite a lot because my work now is sort of similar
21:00the pre-cancer within us is a bit like that unexploded mine
21:05it's a funny parallel really i think for both it is about prevention
21:21that day is really odd i don't like the sun anyway but i think you're possibly a bit conscious
21:30of me because of my cancer but yeah if it's really bright sunshine i do for a baseball hat on or
21:37something whether it's you know closing the door after the horse has bolted i don't know but
21:44trevor is coming to the churchill hospital for a scan that will show how active the cancer cells are
21:49in his tumors after two years of immunotherapy there's a bit of curiosity i think the main
21:58thing is where the treatment goes from this point forward we would love to go to australia and new
22:07zealand because my wife has relatives out there and her brothers in new zealand and we was sort of in
22:15the process of sorting that out when i got my my cancer diagnosed so it's all gone on the back burner
22:23but i don't see the point of thinking too far ahead
22:27i fully expect there's to still be activity there um because cancer is cancer isn't it nobody thinks
22:35you've got to be cured 100 percent
22:45today sarah will hear the results of pre-clinical testing on her lung cancer vaccine
22:52if we're able to trigger an immune reaction it would be a really encouraging sign that we were onto
22:58something hello how much do i want it i mean it matters more than anything
23:11well i think um without much ado z do you want to we're very much looking forward to hearing
23:16the results of your pre-clinical testing
23:18so i've tested the efficacy and i know if i take it during the prime response i get very good efficacy
23:30of the vaccine here you can see the green cells suggesting that the vaccine can be taken by immune
23:37cells directly but i think it's really important to actually do the actual clinical trial to see if
23:44what i'm seeing actually represents what we will see in patients well done very good that's very
23:52exciting the next step is for us to put together a trial package to the mhra and they would like to
23:58see some efficacy data then they'll give us a clinical trial authorization a cta and then we can go ahead
24:05with you know getting the study up and running so we need to get on with it and get the funding that's
24:11the next challenge i hope i'm gonna be able to get funding but actually we haven't so far
24:22well i just put in another application to some funders this is the third time and i'm waiting
24:27to hear whether or not we've been successful so the next few weeks are going to be a little bit
24:30stressful science is always like this unfortunately yeah you have to there's no guarantee of funding
24:37you've got to just keep on going the success of the vaccine depends on something crucial understanding
24:53the earliest stages of cancer's development another area of sarah's research looks for key insight about
25:00how tumors start the milly study is focused on people with a condition called lieframini syndrome
25:09most have inherited a mutation in one of their genes that means that they have a 90 percent risk of
25:17developing cancer and so we're sort of testing an intervention in that group
25:21this study is very important for us because it teaches us about how cancer starts it will help us
25:31design interventions like vaccines that we can then give to communities such as people at high
25:37cancer risk like those with lieframini syndrome but can also be used in a sort of broader context to
25:44protect the general population against cancer in the future 200 people with lieframini syndrome are
25:52being recruited to the study one of them hoping to join is ella when i was nine months old i wasn't
26:00eating i was crying all the time and my mum just couldn't work out what was wrong with me
26:06and the doctors told my mum that she was just being a first-time mum she was just worrying
26:14but my mum was so persistent that eventually i had an ultrasound scan and it was filled a tennis
26:21ball-sized tumour on my adrenal glands this is the scar i've had since i was nine months old
26:29just because of the size of it and because of how small i was they had to make a very large incision
26:37i was literally cut in half and as i've got older and i've grown the scar has just grown with my body
26:44when i was a teenager i always wished i didn't have it and wondered what i'd look like without
26:49it obviously young girls wear prop tops and when i got my belly button pierced i thought
26:54it would look nice but obviously i look different to everyone else but i'm used to it now it's a
26:59representation of what my body's been through and how strong it is i've had this my whole life and
27:04it's the only way i've ever known my body to look
27:10somebody with lee fraumini is at risk of cancer at any time in their life and many will have their
27:17first cancer diagnosis before the age of 30 and then will continue to have cancer diagnoses all the
27:24way through their life and you're in a constant state of vigilance really frightened that any day
27:30now you might get your next cancer when i got diagnosed with west cancer i had six rounds of
27:36chemotherapy and there was then a discussion whether i should have radiotherapy or not
27:42i had the double mastectomy in december 2022 and i had my nipples removed in april 2024
27:50and the mastectomy scar goes all the way under from here to here and then down the front here
28:09a lot of patients with leaf armenia syndrome have been told that it's basically a death sentence and
28:13you are just awaiting for cancer at any given moment hope is everything if you don't have hope then
28:24what are you fighting for hope is what keeps me going every day i wake up and i think that today's
28:29a fresh start the day to try something new i guess when you think about designing a prevention trial you
28:36need to show that your intervention is working and that is hard it's really hard you're waiting for a lack
28:44of cancer hello hi hi ella thank you very much for coming thank you come on in i've had all these
28:56surgeries and they've not even been for preventative measures they say have a preventative mastectomy
29:01have a preventative hysterectomy i've not had any preventative procedures yet i've still had five
29:07major surgeries so it's not about just taking bits out of my body it's about what we can do to stop
29:13having any surgeries at all to stop the cancers from ever happening
29:19right now i don't think my body can take anymore
29:31it's not about to stop the cancers at oxford's churchill hospital professor sarah blagden is
29:44recruiting participants for a trial which may give clues about how cancer starts
29:51ella has lee fraumeni syndrome a g mutation that raises her risk of developing the disease
29:57the lee fraumeni community was very underserved and they have an aberrantly high risk of cancer
30:07so they don't follow the same trajectory as normal cancers and they can't have certain treatments that
30:15others can have and that just seems wrong you know why are we allowing such a high-risk community
30:21to have to you know not test anything in them why why are we letting that happen what sarah learns
30:29from this study will help to design new vaccines to prevent cancer not only in people like ella but
30:35also the rest of the population we know that lee fraumeni is caused by a mutation in the p53 gene
30:44if you imagine your cells as a kind of factory p53 is like the safety manager if anything happens that's
30:50abnormal in the cell the role of p53 is to stop everything pause everything correct whatever's
30:57going wrong and then allow the cell to start up again if it's a situation where the the whatever's
31:05going on in the cell isn't repairable then p53's job is to get rid of the cell altogether if you have
31:13a mutation in p53 the risk of cancer goes up so there was some research carried out in the state
31:21trying to understand exactly what happens in the cells of someone with lfs and one area that keeps
31:28coming up is the mitochondria our mitochondria are tiny structures within our cells that are like
31:37miniature boilers they convert our food into energy which then really powers our entire body
31:45and in people with lee fraumeni syndrome mitochondria are thought to be overactive and a byproduct of
31:53that is that the cells become damaged as the boiler itself is damaged making them much more prone to
32:00cancer studies have shown that an existing diabetes drug called metformin works by turning down that boiler and
32:10and therefore protecting the cells from becoming damaged and this we hope will prevent cancer from
32:17starting and from that i want to start thinking about developing a more targeted drug instead of
32:25metformin or that could be used in addition to metformin and after the study how long until a
32:30drug is developed that can mean lfs patients have access to it yeah i mean it depends what we find it
32:38could be that there is an agent that's already out there that we can repurpose or we could for example
32:43develop something bespoke like a vaccine that you could give and you know we can turn that around
32:49fairly quickly with today's technologies so hopefully within my young lifetime i'm hoping
33:00the information we get from that study is relevant for people beyond that heightened risk population
33:09because this gene also misbehaves in other cancers as well and actually makes them much more aggressive
33:17so it's really helpful for us to understand how and why that happens i think when you see someone
33:24like ella having to sort of have these very serious thoughts and conversations with doctors about her
33:32chance of going just through to the next year without cancer and having to sort of think about
33:37that every day it's very humbling and it's also very shocking and it just it surprises me that more
33:45hasn't been done in the past to help that community and from that community we'll find the answers that
33:51will be important for everyone else so it makes total sense to work in that group and try and help them
33:59i do really think that
34:04i just cannot imagine abandoning them at this point
34:08around 130 people in the uk are diagnosed with lung cancer every day
34:25sarah has an idea under consideration to trial the world's first vaccine to prevent it
34:31it's great to have the idea but it's actually seeing it through that's that that's the painful bit and
34:36we still don't know that we've actually got funding which feels very scary
34:45sarah recently had a funding application refused
34:49i just felt completely traumatized about it
34:53i feel like there is this kind of meteorite that's landing on earth every day that's killing people and
35:00i feel like we've just watched it fall yeah i just felt beside myself i just thought i cannot
35:06i cannot let let this happen
35:10i mean funding is vitally important yeah because without that we can't pay people to do the research
35:17we can't buy the equipment that we need we can't pay to do the analysis we need to do we can't
35:23manufacture a vaccine we can't fund a clinical trial i think if we don't get funding then i think the
35:31momentum would be lost
35:35we are desperate to get the study going so that one day in the future everybody can get the vaccine
35:41my tree your tree i used to sit up there for hours on end just watching everything
35:57cancer's not only a professional challenge but it's also a personal one
36:01mom was recently diagnosed with breast cancer but fortunately quite an early stage
36:11okay so what what are you taking let's have a look um i'm taking those but i have different
36:16ones for morning and different ones so those are your blood thinning agents
36:21i think to some extent it does give you a different perspective when you're kind of on the other side
36:27this one's got to be taken one to be taken each day so that's the breast cancer tablet oh right
36:36actually seeing somebody at home on their own really trying to understand which of their
36:41medicines they need to take it does cast it in a different light so what's the plan well i think
36:48it's the 16th you're having the operation in the afternoon yeah to something rather i think it's in
36:53my diary so i'm going to come and join you right so you're having day surgery and they're going to
36:56take out the the the the nodule yes she's widowed i think it would be horrible time to get you know
37:06to get a really advanced cancer i think it'd be really hard four weeks ago sarah submitted her latest
37:17funding application for the lung cancer vaccine
37:20we really want to make sure that we're describing the the project describing the overall our overall
37:32ambition to um hold oh hey i've just got the i've just got the let me have look i think this is the
37:40email the funding okay it is ah okay right please see the attached feedback from your recent submission
37:55your application for the above study was recently considered and i'm pleased to inform you
38:00that it was recommended for support that's actually that's an ida hold on
38:16z hi hi it's z z just quickly to tell you uh we got the official funding letter we are we have been
38:25funded so congratulations oh well done well done you i'll speak to you later okay bye bye bye
38:35oh my god i can't believe it that is such that's massive
38:45it's a green light we know that we can actually start designing the study and if we show that it's
38:50beneficial then the sky's the limit we can we can just keep designing you know using similar
38:57approaches to prevent other cancers i mean i i've this is a really important i think this is a really
39:03important kind of pivot point in what we're doing
39:20when trevor's skin cancer spread to his liver in 2022 he was given just 12 months to live
39:36today he's at churchill hospital in oxford for the results of a scan that will show just how active
39:41his tumors are good afternoon here again how are you all right 17 17 okay lovely thank you very much
39:55fair to say i know my way around you know you get to know everybody and i see a lot of stuff come and
40:02go a lot of patients come and go as well fortunately in some cases unfortunate in other cases
40:11we are about to see trevor and he has been on our study where he's had immunotherapy in combination
40:19with a targeted drug for two years he's got metastatic melanoma and so he has got about 10
40:28deposits of cancer in his liver so a couple of weeks ago he had a pet scan and my question
40:34was are we still measuring active disease or is this just the the remnants the remains of where his cancer
40:40was positive result will be all the cancers dead and inactive but realistically i'm not expecting
40:47that we're waiting to see we're waiting to see it is uh i'm not jumping the gun and looking ahead
40:57a major part of the job of an oncologist is giving results to our patients
41:02i think sometimes you can just see someone is just desperate just to know and be told things very
41:09clearly and you don't want to extend their misery you don't want to drag it out
41:19knock knock hello hello hi afternoon right i'm just bringing this trolley in yeah
41:24hope you don't mind it's my image station be a good idea great okay so the reason we did the pet scan
41:33was to see whether there was any active tumor cells in there and your scan
41:41shows no active disease was in nothing that's right each lesion is clear
41:46um oh yeah i'm sorry i've
41:55yes
42:01i'm sorry no don't worry
42:02yes yes uh shocked obviously i wouldn't uh
42:21no about the streams i would expect that not at all there was an intake of breath at the meeting
42:31this morning about it really yeah so that means that we can stop the treatment well yes yes
42:40so i can just go home when i sit there so you can go home and have your life back
42:48yeah maybe we can organize our trip to australia now yeah new zealand but yes
42:53so you can safely say you're in remission obviously we don't want to say the word cure
42:57because we don't know no i understand that but um but i think you know this is as good or better than
43:04we could ever have expected lovely thank you very much for that worth the journey up yeah when a
43:12patient like trevor demonstrates that a treatment is working it is so powerful because he's demonstrated
43:20that people with this disease have the potential to benefit from the treatment and that opens so
43:26many doors for other patients with the same condition it's a bit of a hit where you're told you've got
43:31cancer you could have you know 12 months to live so you know that's always in the back of your mind
43:38even though you're feeling great and whatever so it'd be really nice now that i can forget about that
43:45oh i spent some hours sat in this seat having treatment so now i can move on and enjoy life
43:54and enjoy retirement i've just been giving it all clear oh my god thank you very much yes thank you
44:03probably never be back that's what no yes so uh that's really lovely news
44:09it's three years since sarah first had the idea for her lung cancer vaccine
44:24and so today is an important step towards finally delivering it to the public
44:29i think to be able to see and hold the vaccine for me will be a very pivotal moment in my career
44:41hello and to actually have tangible evidence that we can deliver something is going to be extraordinary
44:48wow this is the world's first lung cancer prevention vaccine i can't quite believe it
45:02it's like my third baby
45:06well i just hope that we can get this out as quickly as possible to benefit as many people as possible not
45:13just in the uk but around the world i mean this could be the way that cancer is prevented
45:43the world's first at the world and i think it's important to improve the current cultures and that the world can help us
45:48get to the world's first place to the Outreach Care that we can get to the world and will be the hope that the health of the world is very important
45:51once the majority of our panelists have been able to have a future health insurance that can help us talk about the future
45:57and we're all in the past two weeks and we're not going to be the same with the future
45:59the world and we're looking into the community to see how we are going to get the experience in our lives
46:02so you know that we're gonna have to be an end of this kind of opening wall if we can get to see how we're going to Ciao
46:04do it in our mindsets on the world but it's also been doing that our plataformasian that are going to be the same
46:10Transcription by CastingWords
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