Breakthrough Discovery Paves the Way for Treating One of the World’s Most Lethal Cancers

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00:00Breakthrough Discovery paves the way for treating one of the world's most lethal cancers.

00:06Pancreatic cancer, causing over 5% of UK cancer deaths, has a 13% 5-year survival rate.

00:13Symptoms appear post-metastasis, with the lowest survival rate.

00:18An mRNA vaccine trial offers hope by stimulating immune responses to reduce post-surgery recurrence, targeting cancer specifically.

00:30Phase 1 showed the mRNA vaccine, autogene savumarin, activated tumor-specific immune cells, lasting 4 years in sum.

00:40Participants with immune responses had reduced recurrence after 3 years.

00:45The vaccine elicited responses in 50% of 16 participants, marking a breakthrough in early-stage cancer treatment.

00:53In the trial, BioNTech created personalized mRNA vaccines from participants' tumors, combined with chemotherapy and immunotherapy.

01:07These vaccines targeted cancer cell mutations, triggering immune responses.

01:12Among 16 participants, cancer returned in 7, with non-responsive immune systems within 3 years.

01:19In contrast, only 2 of 8 with responsive systems saw recurrence, showcasing the vaccine's potential to enhance outcomes.

01:29Researchers aim to adapt mRNA vaccines for other cancers, as current treatments fail against pancreatic cancer.

01:38Dr. Balachandran emphasizes new therapies' importance, with mRNA vaccines promising better outcomes for the deadliest cancer type.

01:47Dr. Balachand is now on the right side.

01:48Dr. Balachand is now on the right side.

01:49Dr. Balachand is now on the right side.

01:50Dr. Balachand is now on the right side.

01:51Dr. Balachand is now on the right side.

01:52Dr. Balachand is now on the right side.

01:53Dr. Balachand is now on the right side.

01:54Dr. Balachand is now on the right side.

01:55Dr. Balachand is now on the right side.

01:56Dr. Balachand is now on the right side.

01:57Dr. Balachand is now on the right side.

01:58Dr. Balachand is now on the right side.

01:59Dr. Balachand is now on the right side.

02:00Dr. Balachand is now on the right side.

02:01Dr. Balachand is now on the right side.