In quantum physics, the Heisenberg uncertainty principle is the statement that locating a particle in a small region of space makes the momentum of the particle uncertain; and conversely, that measuring the momentum of a particle precisely makes the position uncertain.
In quantum mechanics, the position and momentum of particles do not have precise values, but have a probability distribution. There are no states in which a particle has both a definite position and a definite momentum. The narrower the probability distribution is in position, the wider it is in momentum.
Physically, the uncertainty principle requires that when the position of an atom is measured with a photon, the reflected photon will change the momentum of the atom by an uncertain amount inversely proportional to the accuracy of the position measurement. The amount of uncertainty can never be reduced below the limit set by the principle, regardless of the experimental setup.