00:00blue star news the future of human longevity part 4 b of 5 longevity impact type c irbp
00:11damage rate suppression slows mutation accumulation and stress induced cell death
00:18f o x o 3 stress resistance amplification improve survival under oxidative slash metabolic stress
00:28s i r t 6 genome maintenance enforcement prevents genomic instability and metabolic drift clotho
00:37systemic aging modulation protects vasculature kidneys and brain interpretation c ir bp
00:48equals slows the clock f o x o 3 equals strengthens the system s i r t 6 equals protects
00:58the genome
00:59clotho equals preserves organs therapeutic potential c irbp high potential for protein therapy and gene
01:09therapy could become a core component of rejuvenation cycles f o x o 3 harder to
01:17deliver directly transcription factor drug activation is the most likely path s i r t 6 strong candidate
01:27for gene therapy small molecule activators under development clotho already tested as a circulating
01:34hormone therapy high translational potential for brain and vascular aging comparative table protein
01:43primary function longevity mechanism primary function longevity mechanism human evidence therapeutic path
01:49c ir bprna binding stress protein dna repair rna stabilization mutation suppression emerging protein
02:02therapy gene therapy f o x o 3 transcription factor stress resistance autophagy metabolic
02:13regulation strong drug activation strong drug activation s i r t 6 nuclear deacetylase genome
02:21stability telomere maintenance strong gene therapy activators clotho hormone slash co-receptor vascular
02:31doctor slash brain protection slash brain protection anti-inflammatory strong hormone therapy
02:36you
02:37you
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