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  • 15 hours ago
Your DNA is in a state of continuous movement, and this subtle activity may be crucial to understanding conditions such as cancer, autism, and various developmental disorders.

Recent research from the Salk Institute shows that our genetic material is perpetually folding and unfolding in three-dimensional space. These dynamic loops play a vital role in regulating gene activation, how cells preserve their identities, and the repercussions when this system falters. Errors in DNA folding can have widespread effects throughout the body, leading to developmental issues and cancer progression.

In this video, we explore the mechanics of DNA loops, the reasons for their constant motion, and how scientists have uncovered the unexpected connection between genomic dynamics and human health issues. This groundbreaking finding may pave the way for future treatments that can rectify harmful folding behaviors and restore normal gene function.

If you have a keen interest in genetics, medical advancements, or the intricate workings of your body, this revelation is one you won’t want to overlook.

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Transcript
00:00Your DNA is moving right now.
00:01And that motion could hold the key to cancer and autism.
00:05Inside every cell, two meters of DNA fold and refold nonstop.
00:09This constant motion decides which genes switch on and which stays silent.
00:13Scientists at the Salk Institute just uncovered something stunning.
00:17Different parts of your genome fold at different speeds.
00:20Fast-moving regions often activate important genes.
00:23Slow regions stay quiet.
00:25And this simple difference can shape your identity as a cell.
00:28When researchers disrupted a key protein called NIP-BL, the DNA couldn't loop correctly.
00:34Some regions popped open instantly.
00:37Others took hours.
00:38And the genes inside changed their behavior.
00:41In heart cells and neurons, these DNA dynamics were even more critical.
00:45The folding motion helped each cell remember what it is.
00:49A heart cell. A neuron.
00:51A unique identity written in motion.
00:53But when this system breaks, diseases can follow.
00:56From developmental syndromes to cancers that hijack folding to grow uncontrollably.
01:01Understanding this moving genome may help us correct those errors and reshape how we treat disease.
01:06From medical and cancer.
01:06From medical and cancer.
01:06The ability to remove cancer and access to disease.
01:06Dr.
01:06Dr.
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