00:00Dzień dobry.
00:30Tecnologiczne są pomysły, które pomysły się odbywają, żeby się żyć.
00:33A GENEQUEST, w Tokio, fundator Shoko Takahashi
00:36ofersja simple, saliva-based DNA test
00:39that help people assess their genetic health risks from home.
00:43The idea is to use genetic information
00:45to better understand each person's health profile.
01:00To do czynienia, które są wystarczające,
01:03które są wystarczające,
01:04które są wystarczające,
01:06a także zgodnie,
01:08czy znowu, czy znowu, czy znowu, czy znowu,
01:10czy znowu, czy znowu, czy znowu,
01:12czy znowu, czy znowu, czy znowu.
01:14Prozysze jest simple.
01:16It takes just a few minutes,
01:17and you can do it on your own with the kit provided.
01:20The sample is then sent to a partner company,
01:23which extracts DNA from the submitted saliva,
01:25and then reads it.
01:26A few weeks later, users receive an online report
01:30linking their genes to metabolism and lifestyle risks,
01:33often encouraging healthier habits.
01:36I wonder what changes I'll be advised to make.
01:45Takahashi wants GeneQuest to become
01:47Asia's largest gene analysis company,
01:50building one of Japan's biggest private DNA databases.
01:53As most research focuses on Western populations,
01:57this data could help develop more personalized healthcare
02:00in Japan and beyond.
02:05But the country's biotech innovation goes far beyond prevention.
02:10Now, I'm going to meet a scientist whose work uses the body's own
02:15cellular communication system to deliver drug treatments.
02:19Here in Yokohama, Professor Asako Yamayoshi
02:22is developing ways to deliver cancer drugs only to tumors,
02:26instead of attacking the whole body.
02:29Her research was inspired by a family member who died from cancer
02:33after severe treatment side effects.
02:36Her study uses exosomes, tiny bubbles that already travel through our body,
02:41carrying messages between cells.
02:43She found a way to use these natural messengers.
02:47A molecule ex-hijack oligo can hijack the exome
02:52to carry the nucleic acid drugs, et cetera, to the target cells.
02:58In simple terms, instead of creating artificial carriers,
03:02Yamayoshi's team simply attaches the medicine to these natural taxis,
03:06letting the body deliver the drug itself.
03:10This approach is unique, saving several days and speeding up the process.
03:14Most researchers first extract and purify exosomes in the lab.
03:19It's a complicated procedure.
03:23During this process, exomes are often denatured.
03:28But in our system, we can use the exome inside of the patient directories.
03:35so nucleic acid drugs can bind only to the target genes.
03:40That reduces side effects.
03:43Yamayoshi's system could make treatments faster and easier to scale,
03:48strengthening Japan's position in advanced biotech research.
03:53By working closely with clinicians, the team is refining the technology
03:58and understanding how it could make a real difference in the future.
04:02Professor Yamayoshi proposed a novel way of treatment,
04:06and they directly treat peritoneal metastasis.
04:11Gastric cancer with peritoneal metastasis is very severe disease condition
04:15and difficult to treat.
04:17The exome target treatment reduces the cost of the investigation and the manufacturing.
04:22So it's very important, not only the patient and family,
04:27but also the healthcare system and the healthcare government.
04:32Yamayoshi's team is also testing light-controlled molecules
04:36to switch genes on and off with precision,
04:39another step towards gentler therapies.
04:43From accessible genetic data to targeted treatments,
04:46since Japan's biotech scene is booming
04:48and pioneers like Takahashi and Yamayoshi are leading the way.
04:52MUSIC PD
04:54Takahashiurat
04:54Takahashi
04:57Takahashi
04:57Takahashi
04:57Takahashi
04:57Takahashi
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