NOBEL PRIZE CURE Immune 'Security Guards' Found!  Trump Science Cuts & Peace Prize Ambition MHM NEWS - video Dailymotion

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00:00MEDICINE NOBEL TO TRIO WHO IDENTIFIED IMMUNE SYSTEM'S SECURITY GUARDS

00:09Dear viewers, please like this news, share your comments.

00:15A US-Japanese trio on Monday won the Nobel Prize in Medicine for Research into how the

00:20immune system is kept in check by identifying its security guards, the Nobel jury said.

00:26The discoveries by Mary E. Brunco and Fred Ramsdell of the United States and Japan's

00:32Shimon Sakaguchi have been decisive for understanding how the immune system functions and why we

00:37do not all develop serious autoimmune diseases.

00:40I suppose I could call it a pleasant surprise.

00:43That's the best way to put it.

00:46I thought our research might be useful to people and in clinical settings and that some kind

00:51of reward might come.

00:52But receiving such an honor at this stage is surprising and an honor.

00:57As with so many discoveries, this great leap for humankind began with mice, specifically

01:04male mice, which were born with a host of health problems and died after a few weeks.

01:09Sakaguchi, a professor at the Immunology Frontier Research Center in Osaka, told Swedish broadcaster

01:17Sveriges Radio, it's an honor for me.

01:19I'm looking forward to visiting Stockholm in December to receive the award in person.

01:25The Nobel committee was however unable to reach the two US-based laureates to break the

01:30news to them in person.

01:32If you hear this, call me.

01:34The head of the Nobel assembly, Thomas Perlman, joked at the press conference announcing the

01:39winners.

01:41The three won the prize for research that identified the immune system's security guards, called

01:46regulatory T cells.

01:51Their work concerns peripheral immune tolerance, that prevents the immune system from harming

01:56the body, and has led to a new field of research and the development of potential medical treatments

02:01now being evaluated in clinical trials.

02:04The importance of the discovery is a fundamental principle of how we avoid autoimmunity.

02:13Sakaguchi started all the research when Remstel and Brankov looked at this scurvy mouse.

02:21The hope is to be able to treat or cure autoimmune diseases, provide more effective cancer treatments,

02:39and prevent serious complications after stem cell transplants, the jury said.

02:45Sakaguchi made the first key discovery in 1995.

02:51At the time, many researchers were convinced that immune tolerance only developed due to

02:56potentially harmful immune cells being eliminated in the thymus through a process called central

03:02tolerance.

03:04Sakaguchi, 74, showed that the immune system is more complex and discovered a previously

03:10unknown class of immune cells, which protect the body from autoimmune diseases.

03:15Brunko, born in 1961 and a senior project manager at the Institute for Systems Biology in

03:22Seattle, and Ramsdell, a 64-year-old senior advisor at Sonoma Biotherapeutics in San Francisco,

03:29made the other key discovery in 2001, when they were able to explain why certain mice were particularly

03:35vulnerable to autoimmune diseases.

03:38They had discovered that mice have a mutation in a gene that they named FOXP3, the jury said.

03:44They also showed that mutations in the human equivalent of this gene cause a serious autoimmune

03:49disease .

03:51problem.

03:52Two years later, Sakaguchi was able to link these discoveries.

03:57The trio will receive their prize, a diploma, a gold medal and $1.2 million split three ways,

04:04at a formal ceremony in Stockholm on December 10th.

04:08Researcher from major US institutions typically dominate the Nobel science prize, due largely

04:14to the US long-standing investment in basic science and academic fields.

04:19But that could change down the line following massive per US budget cuts to science programs

04:25announced by the President Donald Trump.

04:28Since January, the US National Institutes of Health has terminated 2,100 research grants totaling around

04:37$9.5 billion and $2.6 billion in contracts, according to an independent database called GrantWatch.

04:46Trump buying peace prize.

04:49Thomas Palman, secretary-general of the committee that awards the Nobel Prize for Medicine, told AFP,

04:57it was no coincidence that the US has by far the most Nobel laureates.

05:04But there is now a creeping sense of uncertainty about the US willingness to maintain their leading

05:12position in research, he said. Trump has meanwhile have made no secret of the fact that he wants

05:20to win a Nobel Einstein, the peace prize. Nobel experts have, however, said his America's first policies

05:27and divisive style give him little chance. It's completely unthinkable,

05:34Owen Stenstein, a historian who has conducted research and co-written a book on the prize.

05:42Trump is, in many ways, the opposite of the ideals that the Nobel Prize represents, he said,

05:50citing multilateral cooperation as an example.

05:55Trump follows his own path unliterally, Stenstein added.

06:01Sudan's network of volunteers, Emergency Response Room, ER, are helping people survive war and famine,

06:08are seen as a possible contender despite amid others, the committee to protect the nurse,

06:12before speak of borders, and dollar navelanya, the window of Kamelein critic Alexei Navalny.

06:20As the first trial on we own, the Nobel Prize in Medicine for research into how the immune system

06:25is kept in check by identifying its secret regards, the Nobel disease says. The discoveries that Mary E.

06:31Brooklyn and Fred Dunstan of the United States and Japan's Shimon Sakaguchi have been decisive

06:36for understanding how the immune system functions and why we do not all develop serious autoimmune diseases.

06:51The math and this is a question of what I think is a process of implementing an evolutionary system for science,

06:57because, of course, the behavior of the

NOBEL PRIZE CURE Immune 'Security Guards' Found! Trump Science Cuts & Peace Prize Ambition MHM NEWS

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