00:00You four are the smartest doctors I could find.
00:05What does this family history tell us?
00:07A presumptive diagnosis of fatal familial insomnia,
00:10which you've highlighted in red,
00:12shows up in every generation of Erica's family.
00:14But the pattern's unusual.
00:16Her father's one of six siblings,
00:17but he's the only one to contract FFI.
00:21Are you nodding because you agree with me,
00:23or are you trying to think of a way to make fun of my accent?
00:25Bless your heart, Dr. Lubbock.
00:27I wouldn't ever.
00:29FFI is autosomal dominant.
00:31You can only inherit the gene from an affected parent.
00:33But if they had it, you got a straight 50-50 shot.
00:36So Erica's father had five siblings,
00:37each with a 50% chance of getting FFI.
00:40You flip a coin once, comes up heads for FFI.
00:43What are the odds that you flip a coin five more times,
00:47and it comes up tails?
00:48One half to the power of five, a little better than 3%.
00:52Are you saying you don't think Erica's father had FFI?
00:55Whenever we take on a case, we examine every assumption.
00:58We eliminate the impossible.
00:59Whatever remains, however improbable.
01:01However improbable.
01:02Must be the truth.
01:03Must be the truth.
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