The frontrunner for the Republican presidential nomination, who has made a string of incendiary comments on the campaign trail, said Clinton got "schlonged" by Barack Obama.
With a partisan crowd cheering him on, the billionaire real-estate tycoon also took issue with Clinton disappearing during Saturday's televised Democratic debate to go to the bathroom.
"I know where she went, it's disgusting, I don't want to talk about it," Trump said.
"No, it's too disgusting.
Don't say it, it's disgusting, let's not talk, we want to be very, very straight up."
Trump, 69, also once again took aim at the press, describing them as "lying, disgusting people."