Second Son is set seven years after the good ending of Infamous 2, in which Cole MacGrath activated the Ray Field Inhibitor (RFI) to destroy a Conduit (superhumans named for their ability to "channel" powers) named John White, also known as the Beast and cure the Plague. The explosion that resulted was originally thought to have killed all Conduits across the globe; however, those outside of the blast radius or with a natural resistance, have survived. Fearing the Conduits' abilities after the destruction of Empire City, the US eastern seaboard and the worldwide economy, the Department of Unified Protection (DUP) is formed. Now, major cities across the United States are heavily monitored for Conduit activity, whom the DUP have labeled collectively as "bio-terrorists". The game is set in Seattle, Washington, now under DUP jurisdiction. Players control Deslin Rowe a 24 graffiti artist who is a slacker, that wants to help the community by protesting against the government, whom he hates. Because his brother, Reggie, is a police officer, he does not have a good connection with his family, seeming his brother has arrested him numerous times. After trying to help in a bus crash, Deslin comes across a conduit who attacks him. Deslin wakes up with strong healing powers and later finds out he can use power to a more offensive use. Reggie accepts Deslin for being a conduit and helps him to protest against the government... Deslin then finds out that he can defeat other conduits and suck up their power for his use. These powers include, ice, smoke, nature, fire ect. The developers said these powers are "the tip of the iceberg"