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What happens if you don’t sleep? Hour by hour, here’s what sleep deprivation does to your brain and body, and the one thing you may never notice.

Most of us have pulled an all-nighter and survived, but sleep isn’t just downtime. In this video, we break down what happens when you don’t sleep, from the first 24 hours of impaired attention and judgment to what researchers say can happen after 48 hours and 3 days awake, and what the longest recorded attempt can teach us.

We walk through the sleep deprivation stages and the effects of sleep deprivation on the brain and body: the studies comparing a day awake to being legally drunk, why memory can become badly impaired around 36 hours, how the immune system may be affected, and why sleep deprivation hallucinations and distorted perception can show up after about 72 hours. We also explain why we need sleep in the first place, including how the brain clears waste while you rest, and look at the famous case of Randy Gardner, who stayed awake for about 11 days in 1964 under the watch of sleep researchers.

The big reveal is something your brain does that you can’t feel and often never notice, and it’s the reason sleepy driving is so dangerous. If you’ve ever wondered what happens to your body when you don’t sleep, or what happens if you don’t sleep for 24 hours, this video lays out what the research suggests, and where the evidence runs thin.

What’s the longest you’ve ever stayed awake, and what’s the weirdest thing your brain did? Tell us in the comments, and subscribe for more science explained in plain language. If you’re regularly struggling to sleep, it’s worth talking to a doctor.

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Learning
Transcript
00:00Stay awake for about 24 hours, and some studies suggest your brain start performing about
00:04as badly as someone who is legally drunk.
00:07The scary part is that you probably wouldn't notice.
00:09So what actually happens inside your body when you refuse to sleep?
00:12Most of us have pulled an all-nighter and survived, so it feels harmless.
00:16But sleep is not just downtime, it is when your brain does some of its most important
00:20work.
00:21By the end of this video, we will know what happens hour by hour when you skip sleep and
00:25what the longest recorded attempt can teach us.
00:27And there is one thing your brain start doing, after a day or two, a wake that you can't
00:31feel, can't control, and might never notice.
00:33It is the reason sleepy driving is so dangerous.
00:35We will get to it.
00:36Let's start with the first 24 hours.
00:38Your attention sleeps, your judgment gets worse, and your hand-eye coordination drops.
00:42You tend to feel more irritable or anxious, and you crave carbs and sugar food.
00:46Some studies have compared this level of impairment to a blood alcohol level of around 0.10%, that
00:51is over the legal driving event in most areas.
00:53You see why it hits so hard, you need to know what sleep is for.
00:56While you sleep, your brain clears out ways, including a protein called beta amyloid.
01:00You are cleaning systems scientists call the glymphatic system.
01:03Sleep also helps your brain store memories and manage emotions.
01:06Keep it an hour of that maintenance.
01:08Gutskip
01:08By around 36 hours, your memory can become badly impaired.
01:12By 48 hours, your body is struggling.
01:14It still suggests the activity of immune cells that fight viruses and bacteria drops, which
01:18makes you more likely to gut-skip.
01:20Many people also start to feel disconnected from reality, as if their brain is trying to
01:24squeeze in bits of sleep while they are still awake.
01:26After about 72 hours, your perception can become severely distorted.
01:30People record hallucinations, wield more swings, and thinking that resembles psychosis.
01:34Staying awake gets harder, and it can feel almost impossible.
01:38Few studies keep people awake this long.
01:40So much of what we know comes from small experiments and case reports.
01:43So how long can a person actually go?
01:45One famous case is Randy Gardner, a 17-year-old in 1964, who stayed awake for about 11 days
01:51for a science fair project while sleep researchers watched.
01:54He reportedly had proper concentrating, remembering things, and seeing reality clearly.
01:58When it ended, he slept about 14 hours, and then returned to a normal schedule.
02:02But experts don't read that as proof it is safe.
02:05It is one teenager under close supervision, and it is not something to try.
02:08So what is that thing your brain does that you can't feel?
02:10It is called micro-sleep.
02:12When you are barely sleep deprived, your brain can sleep into a sleep-like state for anywhere
02:16from a fraction of a second to about 30 seconds.
02:18Even with your open eyes, you can't decide to do it, and you often don't realize it happened.
02:23At highway speed, even a few seconds is a very long day to travel without anyone in control,
02:27and that is the worst part of sleep loss.
02:29It also hurts your ability to judge how impaired you are.
02:32Your performance dobes, but you stop realizing it.
02:34Sleep is not lazy, it is maintenance, and your brain will take it one way or another.
02:38One bad night is usually recoverable.
02:40But if you are regularly struggling to sleep, or you are often tired despite sleeping,
02:44it is worth taking to a doctor.
02:45What is the longest you have ever stayed awake, and what is the weirdest thing your brain did?
02:49Tell me in the comments.
02:49Bye-bye.
02:52Bye-bye.

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