The NFL announced that the Bills will host the Detroit Lions in Week 2 of the 2026 season on Thursday Night Football, marking the first game ever played at the new Highmark Stadium. The nationally televised matchup is scheduled for Sept. 17 and will stream exclusively on Prime Video, while also being available locally over-the-air in Buffalo. After years of planning and anticipation, Bills fans will finally see their team open the doors to a new era of football in front of a national audience. The matchup also brings added intrigue because it features two teams expected to contend near the top of their respective conferences entering the 2026 season.
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