00:00So, what we are focusing on is that we can understand the complexity of the cancer as well as the
00:08oral cancer
00:10and the gallbladder cancer which is enough in this region, especially in Gangetic Barrel.
00:14If you can see in Uttar Pradesh, there are many cases of gallbladder cancer and prostate.
00:20So, the plan was that if you understand the complexity of the gene signature,
00:27upregulated, down.
00:29And there are many cases of the cancer.
00:32Especially our chemistry colleagues included in this hub.
00:38So, there are many discoveries that we can see that we can see the effects of cancer.
00:45And the discoveries in the lab, go to the clinic.
00:52Only the lab is not left.
00:54So, we can see how much the patients are being used.
00:57So, overall, it was our goal.
00:59And this is not because there are many things like AI and machine learning, deep learning.
01:03So, computer science, who are our colleagues, they were also in the team of cancer.
01:08And their role was to be able to make the diagnosis of cancer.
01:14Instead of getting any questions from somebody else, they may be able to make cure and cure.
01:21So, overall, it is our goal.
01:25People often say genetic disease to cancer.
01:28So, it is not like genetic disease.
01:30If you understand that having a genetic disease is a different thing, it is a different type of genetic disease
01:34toien.
01:34The genetic disease is different, genetic is different.
01:35Cancer has hit a low percentage for men of 4-5% cases.
01:39If someone is in a family, the chances of getting cancer is increased and the chances of getting cancer is
01:46increased.
01:47But geneticism is so important.
01:48You can see that sometimes the genes,
01:52a kooshika in your nucleus,
01:55and in your chromosomes,
01:57in which the DNA is available,
02:00sometimes there are changes.
02:03The changes in the DNA,
02:05the changes in the DNA,
02:10or the proteins,
02:11are effective.
02:13Sometimes there are some genes that promote cancer.
02:18Oncogenes,
02:18they will drive cancer.
02:20If you have a car,
02:22you have put a gas button on it.
02:27It is an accelerator.
02:29The other genes are tumor suppressors,
02:32which stop the tumor.
02:34So, tumor suppressors,
02:37they are more than in the cancer.
02:41They are less than inactive.
02:43This is why genomics is a very important role.
02:47Because it tells you,
02:48in which cancer,
02:48in which type of aberration,
02:50in which type of changes are happening.
02:53I will give you an example.
02:54I will give you an example.
02:55We talk about synthetic lethal lethal.
03:02You think that if there is a pathway,
03:05there are two types of genes.
03:07There are two types of genes.
03:09If there are two genes,
03:11if there are A and B,
03:13there are two genes.
03:13If A is negative,
03:14then B will increase.
03:19If A is negative,
03:21then B will increase.
03:21then B will increase.
03:22then A will increase.
03:23You have to do that,
03:24if A is negative,
03:25then B will also stop you.
03:28So,
03:28the cancer cells can die.
03:29If A is negative,
03:31So,
03:31with these things,
03:33people check the DNA repair genes,
03:36such as BRCA1, BRCA2.
03:38Some cancer patients,
03:40if BRCA1, BRCA2,
03:41there are mutations in BRCA1,
03:42that means,
03:42the genes are not working.
03:44So,
03:44one patient has a drug,
03:47is PARP inhibitor.
03:48Because PARP is doing DNA repair.
03:50So,
03:50when it is inhibitor,
03:51then you have two channels.
03:55One was made by mutation.
03:57One was made by mutation.
03:57The other one was made by PARP inhibitor.
03:59This is a major issue.
04:01a cancer cell causes the type of mutation.
04:03this chemical genequia is pretty important.
04:07This is why
04:09then,
04:09whether there is any mutation or mutation,
04:11if you have any mutation or any aberration,
04:13then you have to understand
04:13which procedures will be you.
04:16Which forces you may be able to work?
04:16Which forces you may be able to work?
04:18Which Of which means?
04:18Which members of these組織 and co-dependent Co-dependent partners
04:19and as a
04:20block can be done.
04:24Now, there are some labs, like
04:27some big hospitals have been there.
04:30Genomic sequencing is not happening.
04:33But we need to advance advance level
04:36because we have to do a component of cancer
04:44which is not made from genomic data.
04:46There are some labs here and there are
04:48There are gene panels, which are often private hospitals and government hospitals.
04:55But as a result, gene sequencing, all cancers systematically store data, interpret it,
05:05and see which genes are up-regulated or down-regulated,
05:10after thinking about which drugs are effective.
Comments