Fibromyalgia: Is It an Immune System Issue Rather Than a Brain Disorder?

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00:00Fibromyalgia. Is it an immune system issue rather than a brain disorder?

00:06Fibromyalgia causes widespread pain, fatigue, and fibrofog.

00:10Debate exists on whether it's linked to autoimmune disorders with increasing consensus.

00:19Autoimmunity involves an immune response where the system mistakenly attacks healthy tissues,

00:24causing damage, inflammation, and diseases.

00:26It includes organ-specific and systemic diseases, impacting various body parts and functions.

00:37Organ-specific autoimmune diseases include type 1 diabetes, multiple sclerosis, and thyroid disorders.

00:44Systemic diseases include lupus, rheumatoid arthritis, and inflammatory bowel disease.

00:49Fatigue burdens those with complex conditions, while unexplained weight changes disrupt lives.

01:00Dizziness impairs balance and well-being, and difficulty focusing affects concentration,

01:05impacting daily tasks for many battling autoimmune disorders.

01:09Fibromyalgia was once considered autoimmune but lacked inflammation markers.

01:18Recent findings suggest neurological mechanisms prompting re-evaluation.

01:23It's viewed as a brain pain processing disorder, highlighting nocyplastic pain,

01:27and shared chronic condition mechanisms.

01:29Researchers discovered elevated autoantibody levels for serotonin, phospholipids,

01:39gangliocides, and thyroid glands in fibromyalgia patients,

01:42with occurrence rates varying between 19% and 73%.

01:46Some fibromyalgia subgroups exhibit immune abnormalities.

01:54A 2022 study found 19 inflammatory proteins.

01:59Evidence suggests autoimmunity enabling future targeted treatments.