The Mamba Venom is a Double Trap: Science Reveals Why Antivenom Fails.

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Science has just solved a medical mystery that has cost thousands of lives in Africa: Black Mamba antivenom can make the venom MORE LETHAL. Understand the "double-strike" strategy and why new treatments are needed URGENTLY. #BlackMamba #Antivenom #SnakeVenomFacts

Transcript

00:00The Mamba's Double Trap, The Secret Behind Anti-Venom Failure

00:04Hello and welcome to a new segment that takes us deep into a medical and biological mystery

00:09that has cost thousands of lives, the Black Mamba S-Venom.

00:14For years, doctors treating bites from this snake, one of the deadliest on the planet,

00:19have witnessed a terrifying pattern.

00:21Patients would improve after receiving the anti-venom,

00:24only to suddenly fall into a painful decline.

00:26Today, that enigma has been solved.

00:29Crucial research from the University of Queensland has revealed the truth.

00:33The venom of three Mamba species, the Black Mamba, the Western Green Mamba,

00:38and Jameson's Mamba is far more complex and vicious than we imagined.

00:41It's not one attack, but a double-strike strategy.

00:45It is the hidden reason why anti-venom fails in the final stage,

00:48the coordinated attack, flexidity, and spasm.

00:52We used to believe the Mamba employed a single primary chemical weapon.

00:55The study refutes this and confirms that it executes a coordinated attack

00:59at two points in the nervous system.

01:01First strike, flaccid paralysis.

01:04When the victim is bitten, they experience flaccid paralysis, the limp paralysis.

01:09This is the phase of postsynaptic toxicity,

01:11and we must say that current anti-venoms are quite effective at neutralizing this initial effect.

01:17Second strike, spastic paralysis.

01:19Herein lies the hidden danger.

01:23The research found that upon administering the anti-venom,

01:26the drug itself unmasks a second completely separate attack.

01:30This hidden component strikes another part of the nervous system,

01:33causing a second, much more severe type of paralysis, spastic paralysis.

01:38This is characterized by painful spasms and uncontrolled muscle contractions.

01:43In essence, the venom first blocks nerve signals from reaching the muscles.

01:48But once the anti-venom clears that block,

01:50the hidden components of the venom suddenly overstimulate the muscles.

01:53It is, as one researcher described it,

01:56treating one disease and suddenly revealing another.

01:59Global Implications and the Call to Action

02:01This revelation about the double strike mechanism has profound implications for global health.

02:07Mamba bites, or dendrosbis species, are a constant threat in sub-Saharan Africa.

02:12Responsible for up to 30,000 deaths annually.

02:16The situation is further complicated,

02:18because the study also found that the venom's function varies notably,

02:22according to the Snake-S geographical location,

02:25especially in black mamba populations in Kenya and South Africa.

02:29Given that current anti-venoms were not developed to counteract this complexity and variation,

02:34treatment strategies are challenged across different regions.

02:37Researchers are emphatic.

02:39This is not merely an academic finding.

02:41It is a direct call to action for clinicians and anti-venom manufacturers worldwide.

02:47It is urgent to develop specialized anti-venoms that can target the full range of venom activity,

02:52attacking both the first and second strike.

02:55Only then can doctors make better real-time decisions and save lives.

02:59New, more effective treatments are critical to disarming this deadly and hidden second attack.

03:05The mamba's double trap has been exposed.

03:07Science now has the map to defeat it.

03:09Money experience.

03:10Money experience.

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