Malapelle: “I test genetici e genomici fondamentali per la prevenzione e cura delle neoplasie”
(Adnkronos) - “I test genetici e genomici sono fondamentali dal punto di vista terapeutico perché possono aprire un ventaglio di soluzioni differenti nella cura di alcune neoplasie”. Così Umberto Malapelle, Direttore del Laboratorio di Patologia Molecolare Predittiva Dipartimento di Sanità Pubblica, Università Federico II di Napoli, a margine del convegno sul tumore ovarico patrocinato da ACTO Campania e sponsorizzato da GSK.
Category
🗞
NewsTranscript
00:00The difference lies in the fact that with a genomic test we can identify typical features of neoplasia
00:07while with genetic tests we can identify features that go beyond neoplasia and can be transmitted in the family.
00:13And so they require the care of the entire family, not just the patient.
00:18On the other hand, however, they open the possibility of prevention
00:21because we can identify an alteration that can be followed in the family and prevent the development of a tumor.
00:26Genomic tests are fundamental from a therapeutic point of view
00:29because they allow us to identify those features, in this case genomic,
00:32that identify the population of patients that can be treated against a molecular target,
00:36in the context of PARP inhibitor drugs.
00:39How can we access them?
00:41There are institutions, for example in the Campania region, such as Federico II,
00:44or PASCAL, which offer this type of test to patients with high-degree cirrhosis tumors,
00:49which therefore allow us to identify this specific sub-population
00:52that can benefit from PARP inhibitors.
00:55There are many opportunities because,
00:57especially when these tests are conducted in the context of an extensive genomic profile,
01:02they allow us to identify alterations in different genes
01:05that can open different therapeutic ventricles.
01:08One of the main links that must be worked on is the refundability of these tests,
01:12especially to make it automatic,
01:14as well as when the drugs are approved,
01:17and to offer it to the entire general population on a national scale.