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George Simmons (Adam Sandler) is a middle-aged retired stand-up comedian turned movie star. Despite his wealth he is disillusioned and depressed as most of his recent film work is low-brow and poorly received. He is diagnosed with acute myeloid leukemia and offered an experimental treatment that has only an eight-percent chance of therapeutic response. Believing he is about to die, he returns to his roots of stand-up comedy.
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